Reaction Details Report a problem with these data
Target
Transient receptor potential cation channel subfamily V member 1
Ligand
BDBM50188644
Substrate
n/a
Meas. Tech.
ChEMBL_364426 (CHEMBL870234)
IC50
9±n/a nM
Citation
Ognyanov, VI; Balan, C; Bannon, AW; Bo, Y; Dominguez, C; Fotsch, C; Gore, VK; Klionsky, L; Ma, VV; Qian, YX; Tamir, R; Wang, X; Xi, N; Xu, S; Zhu, D; Gavva, NR; Treanor, JJ; Norman, MH Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles. J Med Chem 49:3719-42 (2006) [PubMed] Article
More Info.:
Target
Name:
Transient receptor potential cation channel subfamily V member 1
Synonyms:
Capsaicin receptor | OTRPC1 | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Trpv1 | Vanilloid Receptor 1 (TRPV1, VR1) | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 (VRI/TRPV1) | Vanilloid receptor type 1-like | Vanilloid receptor type 1-like (TrpV1/Vr1) | Vr1 | Vr1l | osm-9-like TRP channel 1
Type:
Transient Receptor
Mol. Mass.:
94956.12
Organism:
Rattus norvegicus (rat)
Description:
O35433
Residue:
838
Sequence:
MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASPLDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDAVAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVARKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIEDGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSGRVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK
Inhibitor
Name:
BDBM50188644
Synonyms:
6-(trifluoromethyl)-4-(4-(trifluoromethyl)cyclohexyl)-2-(4-(3-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-1H-benzo[d]-imidazole | CHEMBL208580
Type:
Small organic molecule
Emp. Form.:
C25H24F9N5
Mol. Mass.:
565.4772
SMILES:
FC(F)(F)C1CCC(CC1)c1cc(cc2[nH]c(nc12)N1CCN(CC1)c1ncccc1C(F)(F)F)C(F)(F)F |(3.4,7.16,;3.41,5.61,;4.95,5.61,;1.87,5.6,;3.41,4.07,;4.74,3.29,;4.73,1.76,;3.4,.99,;2.06,1.76,;2.07,3.3,;3.39,-.55,;4.72,-1.32,;4.72,-2.86,;3.39,-3.62,;2.06,-2.85,;.6,-3.33,;-.3,-2.08,;.6,-.84,;2.07,-1.32,;-1.84,-2.08,;-2.61,-3.41,;-4.15,-3.42,;-4.91,-2.08,;-4.16,-.75,;-2.61,-.75,;-6.45,-2.09,;-7.22,-.75,;-8.76,-.76,;-9.53,-2.1,;-8.75,-3.43,;-7.21,-3.42,;-6.43,-4.75,;-5.67,-6.07,;-5.1,-3.98,;-7.76,-5.54,;6.05,-3.63,;7.38,-4.39,;5.28,-4.96,;6.83,-2.3,)|