Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50304286
Substrate
n/a
Meas. Tech.
ChEMBL_605777 (CHEMBL1074595)
Ki
16300±n/a nM
Citation
 Micale, N; Ettari, R; Schirmeister, T; Evers, A; Gelhaus, C; Leippe, M; Zappalà, M; Grasso, S Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors. Bioorg Med Chem 17:6505-11 (2009) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
  
Inhibitor
Name:
BDBM50304286
Synonyms:
2-Amino-1-(4-methoxyphenyl)-6,7-methylenedioxy-2H-isoquinolin-3-one | CHEMBL596442
Type:
Small organic molecule
Emp. Form.:
C17H14N2O4
Mol. Mass.:
310.3041
SMILES:
COc1ccc(cc1)-c1n(N)c(=O)cc2cc3OCOc3cc12
Structure:
Search PDB for entries with ligand similarity: