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Target
Mitogen-activated protein kinase 11
Ligand
BDBM50421126
Substrate
n/a
Meas. Tech.
ChEMBL_839530 (CHEMBL2090337)
IC50
300±n/a nM
Citation
 Tynebor, RM; Chen, MH; Natarajan, SR; O'Neill, EA; Thompson, JE; Fitzgerald, CE; O'Keefe, SJ; Doherty, JB Synthesis and biological activity of pyridopyridazin-6-one p38a MAP kinase inhibitors. Part 2. Bioorg Med Chem Lett 22:5979-83 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 11
Synonyms:
MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B
Type:
Enzyme
Mol. Mass.:
41390.66
Organism:
Mus musculus (mouse)
Description:
Q9WUI1
Residue:
364
Sequence:
MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTHEIEQ
  
Inhibitor
Name:
BDBM50421126
Synonyms:
CHEMBL2088585
Type:
Small organic molecule
Emp. Form.:
C20H11F3N2O2
Mol. Mass.:
368.3087
SMILES:
Fc1ccc(Oc2ccc3c(-c4ccccc4F)c(=O)ccn3n2)c(F)c1 |(32.52,-8.2,;32.51,-6.66,;31.17,-5.89,;31.17,-4.35,;32.5,-3.58,;32.5,-2.04,;31.16,-1.27,;31.15,.27,;29.82,1.02,;28.5,.25,;27.17,1.02,;27.17,2.56,;28.51,3.33,;28.5,4.88,;27.17,5.64,;25.84,4.87,;25.84,3.33,;24.5,2.56,;25.84,.25,;24.5,1.02,;25.84,-1.29,;27.17,-2.06,;28.51,-1.28,;29.83,-2.04,;33.84,-4.34,;35.16,-3.56,;33.85,-5.88,)|
Structure:
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