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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50430144
Substrate
n/a
Meas. Tech.
ChEMBL_942935 (CHEMBL2342884)
IC50
29±n/a nM
Citation
 Udagawa, S; Sakami, S; Takemura, T; Sato, M; Arai, T; Nitta, A; Aoki, T; Kawai, K; Iwamura, T; Okazaki, S; Takahashi, T; Kaino, M Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1. Bioorg Med Chem Lett 23:1617-21 (2013) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
  
Inhibitor
Name:
BDBM50430144
Synonyms:
CHEMBL2338242
Type:
Small organic molecule
Emp. Form.:
C20H29N3O2
Mol. Mass.:
343.4632
SMILES:
Cn1ncc2c1C(C)(C)CCN([C@H]1C3CC4CC1C[C@@](O)(C4)C3)C2=O |r,wU:12.12,19.21,TLB:16:15:22:18.17.12,16:17:21.15.14:22,12:13:21:18.16.17,THB:12:17:21:14.13.22,11:12:21.15.14:22,(8.15,-31.75,;8.91,-33.08,;8.27,-34.48,;9.4,-35.52,;10.75,-34.76,;10.44,-33.25,;11.43,-32.07,;10.09,-31.3,;11.42,-30.53,;12.96,-32.11,;13.89,-33.34,;13.52,-34.83,;14.7,-35.82,;16.09,-35.23,;17.14,-36.45,;17.15,-38.03,;15.75,-38.61,;14.72,-37.35,;16.12,-37.68,;17.44,-37.18,;18.97,-37.16,;18.65,-38.44,;17.44,-35.69,;12.12,-35.46,;12.08,-37,)|
Structure:
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