Reaction Details Report a problem with these data
Target
Oxa40
Ligand
BDBM50447647
Substrate
n/a
Meas. Tech.
ChEMBL_1289443 (CHEMBL3117137)
IC50
28000±n/a nM
Citation
 Blizzard, TA; Chen, H; Kim, S; Wu, J; Bodner, R; Gude, C; Imbriglio, J; Young, K; Park, YW; Ogawa, A; Raghoobar, S; Hairston, N; Painter, RE; Wisniewski, D; Scapin, G; Fitzgerald, P; Sharma, N; Lu, J; Ha, S; Hermes, J; Hammond, ML Discovery of MK-7655, aß-lactamase inhibitor for combination with Primaxin®. Bioorg Med Chem Lett 24:780-5 (2014) [PubMed]  Article 
Target
Name:
Oxa40
Synonyms:
Beta-lactamase | Class D β-lactamase (OXA-24)
Type:
Enzyme
Mol. Mass.:
30946.50
Organism:
Acinetobacter baumannii
Description:
Q8RLA6
Residue:
275
Sequence:
MKKFILPIFSISILVSLSACSSIKTKSEDNFHISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPASTFKMLNALIGLENHKATTNEIFKWDGKKRTYPMWEKDMTLGEAMALSAVPVYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVNFADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGWLTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
  
Inhibitor
Name:
BDBM50447647
Synonyms:
CHEMBL3112752
Type:
Small organic molecule
Emp. Form.:
C16H20N4O8S
Mol. Mass.:
428.417
SMILES:
N[C@@H](Cc1ccc(NC(=O)[C@@H]2CC[C@@H]3CN2C(=O)N3OS(O)(=O)=O)cc1)C(O)=O |r|
Structure:
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