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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50108770
Substrate
n/a
Meas. Tech.
ChEMBL_1506714 (CHEMBL3598805)
EC50
58±n/a nM
Citation
 Chao, J; Enyedy, I; Van Vloten, K; Marcotte, D; Guertin, K; Hutchings, R; Powell, N; Jones, H; Bohnert, T; Peng, CC; Silvian, L; Hong, VS; Little, K; Banerjee, D; Peng, L; Taveras, A; Viney, JL; Fontenot, J Discovery of biaryl carboxylamides as potent ROR¿ inverse agonists. Bioorg Med Chem Lett 25:2991-7 (2015) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50108770
Synonyms:
CHEMBL3596635
Type:
Small organic molecule
Emp. Form.:
C25H22Cl2FN3O3
Mol. Mass.:
502.365
SMILES:
CN(C(=O)c1c(F)cccc1Cl)c1ncc(cc1OCC1CCC1)-c1cc(ccc1Cl)C(N)=O
Structure:
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