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Found 1466 with Last Name = 'powell' and Initial = 'n'
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18012(trans,trans-4-arylpiperidine-based compound, 1)
Affinity DataIC50:  0.0670nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18033(Ketopiperazine-based inhibitor, 13)
Affinity DataIC50:  0.180nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17967(CHEMBL411885 | Ketopiperazine-based compound, 16 |...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against renin in fluorescent tGFP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18025(2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]prop...)
Affinity DataIC50:  0.420nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50043280(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Affinity DataIC50:  0.490nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17965(N-[2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]p...)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18032(Ketopiperazine-based inhibitor, 12)
Affinity DataIC50:  0.680nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17996(1,4-benzoxazin-3-one, 33 | N-{2-[(2S)-6-(2,4-diami...)
Affinity DataIC50:  0.800nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610140(CHEMBL5266817)
Affinity DataIC50: <1nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17989(1,4-benzoxazin-3-one, 26 | N-{2-[6-(2,4-diamino-6-...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50347563(CHEMBL1801740)
Affinity DataIC50:  1.60nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610139(CHEMBL5287698)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610137(CHEMBL5269111)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425864(CHEMBL2312649)
Affinity DataIC50:  2nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18005(1,4-benzoxazin-3-one, 42 | methyl N-{2-[6-(2,4-dia...)
Affinity DataIC50:  2nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610136(CHEMBL5274179)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610128(CHEMBL5284310)
Affinity DataIC50:  2nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425870(CHEMBL2311550)
Affinity DataIC50:  3nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108782(CHEMBL3596639)
Affinity DataIC50:  3nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108775(CHEMBL3596638)
Affinity DataIC50:  3nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18001(1,4-benzoxazin-3-one, 38 | N-{2-[6-(2,4-diamino-6-...)
Affinity DataIC50:  3nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610138(CHEMBL5268773)
Affinity DataIC50:  3nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18028((6R)-1-(4-{3-[(2-methoxyphenyl)methoxy]propoxy}phe...)
Affinity DataIC50:  3.20nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18022(Ketopiperazine-based inhibitor, 2)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610129(CHEMBL5276931)
Affinity DataIC50:  5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610134(CHEMBL5280787)
Affinity DataIC50:  5nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426788(CHEMBL2322444)
Affinity DataIC50:  5.10nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425871(CHEMBL2312651)
Affinity DataIC50:  6nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18002(1,4-benzoxazin-3-one, 39 | 3-[6-(2,4-diamino-6-eth...)
Affinity DataIC50:  6nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426777(CHEMBL2322175)
Affinity DataIC50:  6.80nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17988(1,4-benzoxazin-3-one, 25 | 6-(2,4-diamino-6-ethylp...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17995(1,4-benzoxazin-3-one, 32 | N-{2-[6-(2,4-diamino-6-...)
Affinity DataIC50:  7nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17994(1,4-benzoxazin-3-one, 31 | N-{2-[2-(3-chlorophenyl...)
Affinity DataIC50:  7nMAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610127(CHEMBL5269279)
Affinity DataIC50:  7nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18031(CHEMBL193816 | Ketopiperazine-based inhibitor, 11)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50426776(CHEMBL2322176)
Affinity DataIC50:  7nMAssay Description:Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor afterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18031(CHEMBL193816 | Ketopiperazine-based inhibitor, 11)
Affinity DataIC50:  7nMAssay Description:Concentration required to inhibit renin activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM17988(1,4-benzoxazin-3-one, 25 | 6-(2,4-diamino-6-ethylp...)
Affinity DataIC50:  7.10nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
TargetRenin(Homo sapiens (Human))
Pfizer

LigandPNGBDBM18026(2-(7-{[(2R)-1-(4-{3-[(2-methoxyphenyl)methoxy]prop...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:The renin assay utilized a tandem Green Flourescent Protein (tGFP) substrate that was hydrolyzed by human rennin. The tGFP substrate contained a nine...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50610126(CHEMBL5266943)
Affinity DataIC50:  9nMAssay Description:Inhibition of unphosphorylated BTK (unknown origin) in the presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPDB
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425872(CHEMBL2312650)
Affinity DataIC50:  9nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50425863(CHEMBL2312652)
Affinity DataIC50:  10nMAssay Description:Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50161155(CHEMBL3793229)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at recombinant human GST-tagged ROR-gamma receptor ligand binding domain assessed as inhibition of receptor and co-activator...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108770(CHEMBL3596635)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108770(CHEMBL3596635)
Affinity DataIC50:  10nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108900(CHEMBL3596631)
Affinity DataIC50:  11nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50108898(CHEMBL3596629)
Affinity DataIC50:  11nMAssay Description:Inverse agonist activity at human recombinant GST-tagged RORgammat ligand binding domain assessed as effect on receptor-biotin tagged TRAP220 co-acti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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