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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM203831
Substrate
n/a
Meas. Tech.
Monoamine Oxidase Assay
pH
7.4±n/a
Temperature
311.15±n/a K
IC50
3.2e+3± 1.2e+3 nM
Comments
extracted
Citation
 Leng, J; Qin, HL; Zhu, K; Jantan, I; Hussain, MA; Sher, M; Amjad, MW; Naeem-Ul-Hassan, M; Ahmad, W; Bukhari, SN Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chem Biol Drug Des 88:889-898 (2016) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
  
Inhibitor
Name:
BDBM203831
Synonyms:
(2E)-2-[(2-chloro-3-methoxyphenyl)methylidene]-4-methyl-1,2,3,4-tetrahydronaphthalen-1-one (3d)
Type:
Small organic molecule
Emp. Form.:
C19H17ClO2
Mol. Mass.:
312.79
SMILES:
COc1cccc(\C=C2/CC(C)c3ccccc3C2=O)c1Cl
Structure:
Search PDB for entries with ligand similarity: