Reaction Details Report a problem with these data
Target
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Ligand
BDBM481688
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Kd
16±n/a nM
Citation
 Waldmann, H; Martin-Gago, PA; Murarka, S; Klein, C; Bastiaens, P; Wittinghofer, A; Fansa, EK Benzene disulfonamide for the treatment of cancer US Patent  US10913710 Publication Date 2/9/2021 
Target
Name:
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Synonyms:
3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Type:
PROTEIN
Mol. Mass.:
17418.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105761
Residue:
150
Sequence:
MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLFYV
  
Inhibitor
Name:
BDBM481688
Synonyms:
N1-benzyl-N1-(2-chlorobenzyl)-N4- cyclopentylbenzene-1,4- disulfonamide | US10913710, Compound 98
Type:
Small organic molecule
Emp. Form.:
C25H27ClN2O4S2
Mol. Mass.:
519.076
SMILES:
Clc1ccccc1CN(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)S(=O)(=O)NC1CCCC1
Structure:
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