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Compile Data Set for Download or QSAR

Found 287 hits Enz. Inhib. hit(s) with all data for entry = 1705   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336260
PNG
(US9744172, Compound UNC00000569A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(F)cc1
Show InChI InChI=1S/C22H29FN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15?,18-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336261
PNG
(US9744172, Compound UNC00000570A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(nc1)N1CCNCC1
Show InChI InChI=1S/C25H37N9/c1-2-3-10-28-25-30-16-21-23(19-6-9-22(29-15-19)33-13-11-27-12-14-33)32-34(24(21)31-25)17-18-4-7-20(26)8-5-18/h6,9,15-16,18,20,27H,2-5,7-8,10-14,17,26H2,1H3,(H,28,30,31)/t18?,20-
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n/an/a<10n/an/an/an/an/an/a



The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336262
PNG
(US9744172, Compound UNC583A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H38N8/c1-2-3-12-29-26-30-17-23-24(20-6-10-22(11-7-20)33-15-13-28-14-16-33)32-34(25(23)31-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21,28H,2-5,8-9,12-16,18,27H2,1H3,(H,29,30,31)/t19?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336263
PNG
(US9744172, Compound UNC582A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-10-22(11-7-20)32-13-15-34-16-14-32)31-33(25(23)30-26)18-19-4-8-21(27)9-5-19/h6-7,10-11,17,19,21H,2-5,8-9,12-16,18,27H2,1H3,(H,28,29,30)/t19?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336265
PNG
(US9744172, Compound UNC580A)
Show SMILES N[C@H]1CCC(Cn2nc(-c3ccc(F)cc3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C27H31FN6/c28-22-12-10-21(11-13-22)25-24-17-31-27(30-16-4-7-19-5-2-1-3-6-19)32-26(24)34(33-25)18-20-8-14-23(29)15-9-20/h1-3,5-6,10-13,17,20,23H,4,7-9,14-16,18,29H2,(H,30,31,32)/t20?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336266
PNG
(US9744172, Compound UNC586A)
Show SMILES N[C@H]1CCC(Cn2nc(-c3ccc(nc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C30H39N9/c31-25-11-8-23(9-12-25)21-39-29-26(20-35-30(36-29)33-14-4-7-22-5-2-1-3-6-22)28(37-39)24-10-13-27(34-19-24)38-17-15-32-16-18-38/h1-3,5-6,10,13,19-20,23,25,32H,4,7-9,11-12,14-18,21,31H2,(H,33,35,36)/t23?,25-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384584
PNG
(CHEMBL2036807 | US9744172, Compound UNC607A)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H40N8/c32-26-12-8-24(9-13-26)22-39-30-28(21-35-31(36-30)34-16-4-7-23-5-2-1-3-6-23)29(37-39)25-10-14-27(15-11-25)38-19-17-33-18-20-38/h1-3,5-6,10-11,14-15,21,24,26,33H,4,7-9,12-13,16-20,22,32H2,(H,34,35,36)/t24-,26-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336268
PNG
(US9744172, Compound UNC608A)
Show SMILES N[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCOCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H39N7O/c32-26-12-8-24(9-13-26)22-38-30-28(21-34-31(35-30)33-16-4-7-23-5-2-1-3-6-23)29(36-38)25-10-14-27(15-11-25)37-17-19-39-20-18-37/h1-3,5-6,10-11,14-15,21,24,26H,4,7-9,12-13,16-20,22,32H2,(H,33,34,35)/t24-,26-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336270
PNG
(US9744172, Compound UNC593A)
Show SMILES CCCCNc1ncc2c(nn(C[C@@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-8-21(9-7-20)32-15-13-27-14-16-32)31-33(25(23)30-26)18-19-4-10-22(34)11-5-19/h6-9,17,19,22,27,34H,2-5,10-16,18H2,1H3,(H,28,29,30)/t19-,22+
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336273
PNG
(US9744172, Compound UNC603A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C26H37N7O/c1-2-3-12-28-26-29-17-23-24(20-6-8-21(9-7-20)32-15-13-27-14-16-32)31-33(25(23)30-26)18-19-4-10-22(34)11-5-19/h6-9,17,19,22,27,34H,2-5,10-16,18H2,1H3,(H,28,29,30)/t19-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336276
PNG
(US9744172, Compound UNC601A)
Show SMILES CCCCNc1ncc2c(nn(CC3CCNCC3)c2n1)-c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C25H36N8/c1-2-3-10-28-25-29-17-22-23(20-4-6-21(7-5-20)32-15-13-27-14-16-32)31-33(24(22)30-25)18-19-8-11-26-12-9-19/h4-7,17,19,26-27H,2-3,8-16,18H2,1H3,(H,28,29,30)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336281
PNG
(US9744172, Compound UNC605A)
Show SMILES O[C@H]1CC[C@H](Cn2nc(-c3ccc(cc3)N3CCNCC3)c3cnc(NCCCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C31H39N7O/c39-27-14-8-24(9-15-27)22-38-30-28(21-34-31(35-30)33-16-4-7-23-5-2-1-3-6-23)29(36-38)25-10-12-26(13-11-25)37-19-17-32-18-20-37/h1-3,5-6,10-13,21,24,27,32,39H,4,7-9,14-20,22H2,(H,33,34,35)/t24-,27-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384602
PNG
(CHEMBL2036795 | US9744172, Compound UNC00000344A)
Show SMILES CCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C22H30N6/c1-2-3-13-24-22-25-14-19-20(17-7-5-4-6-8-17)27-28(21(19)26-22)15-16-9-11-18(23)12-10-16/h4-8,14,16,18H,2-3,9-13,15,23H2,1H3,(H,24,25,26)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336323
PNG
(US9744172, Compound UNC00000475A)
Show SMILES CCCCCCNc1ncc2c(nn(CC3CCC(N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C24H34N6/c1-2-3-4-8-15-26-24-27-16-21-22(19-9-6-5-7-10-19)29-30(23(21)28-24)17-18-11-13-20(25)14-12-18/h5-7,9-10,16,18,20H,2-4,8,11-15,17,25H2,1H3,(H,26,27,28)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM50384608
PNG
(CHEMBL2036801 | US9744172, Compound UNC00000471A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4ccccc4)nc23)CC1
Show InChI InChI=1S/C25H28N6/c26-21-13-11-19(12-14-21)17-31-24-22(23(30-31)20-9-5-2-6-10-20)16-28-25(29-24)27-15-18-7-3-1-4-8-18/h1-10,16,19,21H,11-15,17,26H2,(H,27,28,29)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336333
PNG
(US9744172, Compound UNC00000551A)
Show SMILES Cc1ccc(CNc2ncc3c(nn(CC4CCC(N)CC4)c3n2)-c2ccccc2)cc1
Show InChI InChI=1S/C26H30N6/c1-18-7-9-19(10-8-18)15-28-26-29-16-23-24(21-5-3-2-4-6-21)31-32(25(23)30-26)17-20-11-13-22(27)14-12-20/h2-10,16,20,22H,11-15,17,27H2,1H3,(H,28,29,30)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336339
PNG
(US9744172, Compound UNC00000552A)
Show SMILES NC1CCC(Cn2nc(-c3ccccc3)c3cnc(NCc4cccs4)nc23)CC1
Show InChI InChI=1S/C23H26N6S/c24-18-10-8-16(9-11-18)15-29-22-20(21(28-29)17-5-2-1-3-6-17)14-26-23(27-22)25-13-19-7-4-12-30-19/h1-7,12,14,16,18H,8-11,13,15,24H2,(H,25,26,27)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336354
PNG
(US9744172, Compound UNC705A)
Show SMILES CCCNc1ncc2c(nn(C3CCCCC3)c2n1)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C21H25N5O2/c1-2-12-22-21-23-13-17-18(14-8-10-15(11-9-14)20(27)28)25-26(19(17)24-21)16-6-4-3-5-7-16/h8-11,13,16H,2-7,12H2,1H3,(H,27,28)(H,22,23,24)
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336362
PNG
(US9744172, Compound UNC978A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C22H30N6O3S/c1-3-4-13-23-22-24-14-19-20(15-5-7-16(8-6-15)27-32(2,30)31)26-28(21(19)25-22)17-9-11-18(29)12-10-17/h5-8,14,17-18,27,29H,3-4,9-13H2,1-2H3,(H,23,24,25)/t17?,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336364
PNG
(US9744172, Compound UNC971A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C27H38N6O3S/c1-2-3-17-28-27-29-18-24-25(31-33(26(24)30-27)21-11-13-22(34)14-12-21)19-9-15-23(16-10-19)37(35,36)32-20-7-5-4-6-8-20/h9-10,15-16,18,20-22,32,34H,2-8,11-14,17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336365
PNG
(US9744172, Compound UNC972A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCCC1
Show InChI InChI=1S/C27H38N6O3S/c1-2-3-17-28-27-29-18-24-25(31-33(26(24)30-27)21-11-13-22(34)14-12-21)19-9-15-23(16-10-19)37(35,36)32-20-7-5-4-6-8-20/h9-10,15-16,18,20-22,32,34H,2-8,11-14,17H2,1H3,(H,28,29,30)/t21?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336366
PNG
(US9744172, Compound UNC973A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCC
Show InChI InChI=1S/C25H36N6O3S/c1-3-5-15-26-25-27-17-22-23(30-31(24(22)29-25)19-9-11-20(32)12-10-19)18-7-13-21(14-8-18)35(33,34)28-16-6-4-2/h7-8,13-14,17,19-20,28,32H,3-6,9-12,15-16H2,1-2H3,(H,26,27,29)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336367
PNG
(US9744172, Compound UNC974A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCCC
Show InChI InChI=1S/C25H36N6O3S/c1-3-5-15-26-25-27-17-22-23(30-31(24(22)29-25)19-9-11-20(32)12-10-19)18-7-13-21(14-8-18)35(33,34)28-16-6-4-2/h7-8,13-14,17,19-20,28,32H,3-6,9-12,15-16H2,1-2H3,(H,26,27,29)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336368
PNG
(US9744172, Compound UNC976A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC(C)C
Show InChI InChI=1S/C24H34N6O3S/c1-4-5-14-25-24-26-15-21-22(17-6-12-20(13-7-17)34(32,33)29-16(2)3)28-30(23(21)27-24)18-8-10-19(31)11-9-18/h6-7,12-13,15-16,18-19,29,31H,4-5,8-11,14H2,1-3H3,(H,25,26,27)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336369
PNG
(US9744172, Compound UNC977A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC(C)C
Show InChI InChI=1S/C24H34N6O3S/c1-4-5-14-25-24-26-15-21-22(17-6-12-20(13-7-17)34(32,33)29-16(2)3)28-30(23(21)27-24)18-8-10-19(31)11-9-18/h6-7,12-13,15-16,18-19,29,31H,4-5,8-11,14H2,1-3H3,(H,25,26,27)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336370
PNG
(US9744172, Compound UNC979A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(NS(=O)(=O)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C28H34N6O3S/c1-3-4-17-29-28-30-18-25-26(32-34(27(25)31-28)22-11-13-23(35)14-12-22)20-7-9-21(10-8-20)33-38(36,37)24-15-5-19(2)6-16-24/h5-10,15-16,18,22-23,33,35H,3-4,11-14,17H2,1-2H3,(H,29,30,31)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336372
PNG
(US9744172, Compound UNC983A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC
Show InChI InChI=1S/C23H32N6O3S/c1-3-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)26-4-2)28-29(22(20)27-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,26,30H,3-5,8-11,14H2,1-2H3,(H,24,25,27)/t17?,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336373
PNG
(US9744172, Compound UNC984A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCC
Show InChI InChI=1S/C23H32N6O3S/c1-3-5-14-24-23-25-15-20-21(16-6-12-19(13-7-16)33(31,32)26-4-2)28-29(22(20)27-23)17-8-10-18(30)11-9-17/h6-7,12-13,15,17-18,26,30H,3-5,8-11,14H2,1-2H3,(H,24,25,27)/t17?,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336374
PNG
(US9744172, Compound UNC986A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCOCC1
Show InChI InChI=1S/C26H36N6O4S/c1-2-3-14-27-26-28-17-23-24(30-32(25(23)29-26)20-6-8-21(33)9-7-20)18-4-10-22(11-5-18)37(34,35)31-19-12-15-36-16-13-19/h4-5,10-11,17,19-21,31,33H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336375
PNG
(US9744172, Compound UNC987A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCOCC1
Show InChI InChI=1S/C26H36N6O4S/c1-2-3-14-27-26-28-17-23-24(30-32(25(23)29-26)20-6-8-21(33)9-7-20)18-4-10-22(11-5-18)37(34,35)31-19-12-15-36-16-13-19/h4-5,10-11,17,19-21,31,33H,2-3,6-9,12-16H2,1H3,(H,27,28,29)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336378
PNG
(US9744172, Compound UNC1032A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-2-3-16-30-28-31-18-25-26(34-35(27(25)33-28)22-10-12-23(36)13-11-22)20-6-14-24(15-7-20)39(37,38)32-17-19-4-8-21(29)9-5-19/h4-9,14-15,18,22-23,32,36H,2-3,10-13,16-17H2,1H3,(H,30,31,33)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336379
PNG
(US9744172, Compound UNC1033A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCc1ccc(F)cc1
Show InChI InChI=1S/C28H33FN6O3S/c1-2-3-16-30-28-31-18-25-26(34-35(27(25)33-28)22-10-12-23(36)13-11-22)20-6-14-24(15-7-20)39(37,38)32-17-19-4-8-21(29)9-5-19/h4-9,14-15,18,22-23,32,36H,2-3,10-13,16-17H2,1H3,(H,30,31,33)/t22?,23-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336380
PNG
(US9744172, Compound UNC1035A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C26H36N6O3S/c1-2-3-16-27-26-28-17-23-24(30-32(25(23)29-26)20-10-12-21(33)13-11-20)18-8-14-22(15-9-18)36(34,35)31-19-6-4-5-7-19/h8-9,14-15,17,19-21,31,33H,2-7,10-13,16H2,1H3,(H,27,28,29)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336381
PNG
(US9744172, Compound UNC1036A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C26H36N6O3S/c1-2-3-16-27-26-28-17-23-24(30-32(25(23)29-26)20-10-12-21(33)13-11-20)18-8-14-22(15-9-18)36(34,35)31-19-6-4-5-7-19/h8-9,14-15,17,19-21,31,33H,2-7,10-13,16H2,1H3,(H,27,28,29)/t20?,21-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336383
PNG
(US9744172, Compound UNC1059A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC
Show InChI InChI=1S/C24H34N6O3S/c1-3-5-15-25-24-26-16-21-22(17-6-12-20(13-7-17)34(32,33)27-14-4-2)29-30(23(21)28-24)18-8-10-19(31)11-9-18/h6-7,12-13,16,18-19,27,31H,3-5,8-11,14-15H2,1-2H3,(H,25,26,28)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336384
PNG
(US9744172, Compound UNC1061A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NCCC
Show InChI InChI=1S/C24H34N6O3S/c1-3-5-15-25-24-26-16-21-22(17-6-12-20(13-7-17)34(32,33)27-14-4-2)29-30(23(21)28-24)18-8-10-19(31)11-9-18/h6-7,12-13,16,18-19,27,31H,3-5,8-11,14-15H2,1-2H3,(H,25,26,28)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336394
PNG
(US9744172, Compound UNC906A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C22H30N6O3S/c1-3-4-13-24-22-25-14-19-20(15-5-11-18(12-6-15)32(30,31)23-2)27-28(21(19)26-22)16-7-9-17(29)10-8-16/h5-6,11-12,14,16-17,23,29H,3-4,7-10,13H2,1-2H3,(H,24,25,26)/t16?,17-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336395
PNG
(US9744172, Compound UNC907A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C22H30N6O3S/c1-3-4-13-24-22-25-14-19-20(15-5-11-18(12-6-15)32(30,31)23-2)27-28(21(19)26-22)16-7-9-17(29)10-8-16/h5-6,11-12,14,16-17,23,29H,3-4,7-10,13H2,1-2H3,(H,24,25,26)/t16?,17-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336401
PNG
(US9744172, Compound UNC913A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC
Show InChI InChI=1S/C23H33N7O2S/c1-3-4-13-26-23-27-14-20-21(17-7-11-19(12-8-17)33(31,32)25-2)29-30(22(20)28-23)15-16-5-9-18(24)10-6-16/h7-8,11-12,14,16,18,25H,3-6,9-10,13,15,24H2,1-2H3,(H,26,27,28)/t16-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336407
PNG
(US9744172, Compound UNC1084A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(N2CCOCC2)c(F)c1
Show InChI InChI=1S/C26H36FN7O/c1-2-3-10-29-26-30-16-21-24(19-6-9-23(22(27)15-19)33-11-13-35-14-12-33)32-34(25(21)31-26)17-18-4-7-20(28)8-5-18/h6,9,15-16,18,20H,2-5,7-8,10-14,17,28H2,1H3,(H,29,30,31)/t18-,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336408
PNG
(US9744172, Compound UNC1085A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(CN2CCOCC2)c(F)c1
Show InChI InChI=1S/C27H38FN7O/c1-2-3-10-30-27-31-16-23-25(33-35(26(23)32-27)17-19-4-8-22(29)9-5-19)20-6-7-21(24(28)15-20)18-34-11-13-36-14-12-34/h6-7,15-16,19,22H,2-5,8-14,17-18,29H2,1H3,(H,30,31,32)/t19-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336409
PNG
(US9744172, Compound UNC1167A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccccc1
Show InChI InChI=1S/C22H30N6/c1-2-3-13-24-22-25-14-19-20(17-7-5-4-6-8-17)27-28(21(19)26-22)15-16-9-11-18(23)12-10-16/h4-8,14,16,18H,2-3,9-13,15,23H2,1H3,(H,24,25,26)/t16-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336410
PNG
(US9744172, Compound UNC1168A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(Br)cc1
Show InChI InChI=1S/C22H29BrN6/c1-2-3-12-25-22-26-13-19-20(16-6-8-17(23)9-7-16)28-29(21(19)27-22)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24H2,1H3,(H,25,26,27)/t15-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336416
PNG
(US9744172, Compound UNC1058A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)NN
Show InChI InChI=1S/C23H32N8O/c1-2-3-12-26-23-27-13-19-20(16-6-8-17(9-7-16)22(32)29-25)30-31(21(19)28-23)14-15-4-10-18(24)11-5-15/h6-9,13,15,18H,2-5,10-12,14,24-25H2,1H3,(H,29,32)(H,26,27,28)/t15-,18-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336417
PNG
(US9744172, Compound UNC1062A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336418
PNG
(US9744172, Compound UNC1063A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C25H34N6O4S/c1-2-3-12-26-25-27-17-22-23(29-31(24(22)28-25)19-6-8-20(32)9-7-19)18-4-10-21(11-5-18)36(33,34)30-13-15-35-16-14-30/h4-5,10-11,17,19-20,32H,2-3,6-9,12-16H2,1H3,(H,26,27,28)/t19?,20-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336419
PNG
(US9744172, Compound UNC1066A)
Show SMILES CCCCNc1ncc2c(nn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)S(=O)(=O)NC1CC1
Show InChI InChI=1S/C24H32N6O3S/c1-2-3-14-25-24-26-15-21-22(28-30(23(21)27-24)18-8-10-19(31)11-9-18)16-4-12-20(13-5-16)34(32,33)29-17-6-7-17/h4-5,12-13,15,17-19,29,31H,2-3,6-11,14H2,1H3,(H,25,26,27)/t18?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336421
PNG
(US9744172, Compound UNC1170A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCOCC1
Show InChI InChI=1S/C27H37N7O2/c1-2-3-12-29-27-30-17-23-24(32-34(25(23)31-27)18-19-4-10-22(28)11-5-19)20-6-8-21(9-7-20)26(35)33-13-15-36-16-14-33/h6-9,17,19,22H,2-5,10-16,18,28H2,1H3,(H,29,30,31)/t19?,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336422
PNG
(US9744172, Compound UNC1179A)
Show SMILES CCCCNc1ncc2c(nn(CC3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)NC
Show InChI InChI=1S/C24H33N7O/c1-3-4-13-27-24-28-14-20-21(17-7-9-18(10-8-17)23(32)26-2)30-31(22(20)29-24)15-16-5-11-19(25)12-6-16/h7-10,14,16,19H,3-6,11-13,15,25H2,1-2H3,(H,26,32)(H,27,28,29)/t16?,19-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM336423
PNG
(US9744172, Compound UNC1171A)
Show SMILES CCCCNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccc(cc1)C(=O)N1CCCC1
Show InChI InChI=1S/C27H37N7O/c1-2-3-14-29-27-30-17-23-24(20-8-10-21(11-9-20)26(35)33-15-4-5-16-33)32-34(25(23)31-27)18-19-6-12-22(28)13-7-19/h8-11,17,19,22H,2-7,12-16,18,28H2,1H3,(H,29,30,31)/t19-,22-
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The University of North Carolina at Chapel Hill

US Patent


Assay Description
The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...


US Patent US9744172 (2017)

More data for this
Ligand-Target Pair
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