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Patent code US10562900

Compile Data Set for Download or QSAR
Found 131 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434536
PNG
(US10562900, Example 14)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434537
PNG
(US10562900, Example 15)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434546
PNG
(US10562900, Example 24)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C29H31Cl2N5O3/c1-17(2)35-11-13-36(14-12-35)20-8-5-18(6-9-20)29(37)32-28-21-10-7-19(15-22(21)33-34-28)25-26(30)23(38-3)16-24(39-4)27(25)31/h5-10,15-17H,11-14H2,1-4H3,(H2,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434549
PNG
(US10562900, Example 27)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CCO)CC3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O4/c1-38-22-16-23(39-2)26(30)24(25(22)29)18-5-8-20-21(15-18)32-33-27(20)31-28(37)17-3-6-19(7-4-17)35-11-9-34(10-12-35)13-14-36/h3-8,15-16,36H,9-14H2,1-2H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434553
PNG
(US10562900, Example 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3cnn(CCO)c3)n[nH]c2c1
Show InChI InChI=1S/C21H19Cl2N5O4/c1-31-15-8-16(32-2)19(23)17(18(15)22)11-3-4-13-14(7-11)26-27-20(13)25-21(30)12-9-24-28(10-12)5-6-29/h3-4,7-10,29H,5-6H2,1-2H3,(H2,25,26,27,30)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434556
PNG
(US10562900, Example 34)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(CN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C25H24Cl2N4O3/c1-31(2)13-14-5-7-15(8-6-14)25(32)28-24-17-10-9-16(11-18(17)29-30-24)21-22(26)19(33-3)12-20(34-4)23(21)27/h5-12H,13H2,1-4H3,(H2,28,29,30,32)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434559
PNG
(US10562900, Example 37)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(CC4)N(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C29H31Cl2N5O3/c1-35(2)19-11-13-36(14-12-19)20-8-5-17(6-9-20)29(37)32-28-21-10-7-18(15-22(21)33-34-28)25-26(30)23(38-3)16-24(39-4)27(25)31/h5-10,15-16,19H,11-14H2,1-4H3,(H2,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434559
PNG
(US10562900, Example 37)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(CC4)N(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C29H31Cl2N5O3/c1-35(2)19-11-13-36(14-12-19)20-8-5-17(6-9-20)29(37)32-28-21-10-7-18(15-22(21)33-34-28)25-26(30)23(38-3)16-24(39-4)27(25)31/h5-10,15-16,19H,11-14H2,1-4H3,(H2,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434561
PNG
(US10562900, Example 45)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C27H27F2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434571
PNG
(US10562900, Example 68)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H30N6O3/c1-16-14-33(15-17(2)28-16)20-7-5-18(6-8-20)27(34)30-26-23-9-10-24(29-25(23)31-32-26)19-11-21(35-3)13-22(12-19)36-4/h5-13,16-17,28H,14-15H2,1-4H3,(H2,29,30,31,32,34)/t16-,17+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434580
PNG
(US10562900, Example 87)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCNC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C26H27Cl2N7O3/c1-26(2)13-35(10-9-30-26)19-8-5-14(12-29-19)25(36)32-24-15-6-7-16(31-23(15)33-34-24)20-21(27)17(37-3)11-18(38-4)22(20)28/h5-8,11-12,30H,9-10,13H2,1-4H3,(H2,31,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434586
PNG
(US10562900, Example 93)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCCCC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C27H26F2N4O3/c1-35-21-15-22(36-2)25(29)23(24(21)28)17-8-11-19-20(14-17)31-32-26(19)30-27(34)16-6-9-18(10-7-16)33-12-4-3-5-13-33/h6-11,14-15H,3-5,12-13H2,1-2H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434591
PNG
(US10562900, Example 98)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(C4)N(C)C)n[nH]c3c2)c1F
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434594
PNG
(US10562900, Example 101)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(OC)c3)n[nH]c2n1
Show InChI InChI=1S/C28H30Cl2N6O4/c1-28(2)14-36(11-10-31-28)18-9-6-15(12-19(18)38-3)27(37)33-26-16-7-8-17(32-25(16)34-35-26)22-23(29)20(39-4)13-21(40-5)24(22)30/h6-9,12-13,31H,10-11,14H2,1-5H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434536
PNG
(US10562900, Example 14)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434537
PNG
(US10562900, Example 15)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434538
PNG
(US10562900, Example 16)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434546
PNG
(US10562900, Example 24)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C29H31Cl2N5O3/c1-17(2)35-11-13-36(14-12-35)20-8-5-18(6-9-20)29(37)32-28-21-10-7-19(15-22(21)33-34-28)25-26(30)23(38-3)16-24(39-4)27(25)31/h5-10,15-17H,11-14H2,1-4H3,(H2,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434547
PNG
(US10562900, Example 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNCC3)n[nH]c2c1
Show InChI InChI=1S/C26H25Cl2N5O3/c1-35-20-14-21(36-2)24(28)22(23(20)27)16-5-8-18-19(13-16)31-32-25(18)30-26(34)15-3-6-17(7-4-15)33-11-9-29-10-12-33/h3-8,13-14,29H,9-12H2,1-2H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434550
PNG
(US10562900, Example 28)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NC(=O)CN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C26H25Cl2N5O4/c1-33(2)13-21(34)29-16-8-5-14(6-9-16)26(35)30-25-17-10-7-15(11-18(17)31-32-25)22-23(27)19(36-3)12-20(37-4)24(22)28/h5-12H,13H2,1-4H3,(H,29,34)(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434554
PNG
(US10562900, Example 32)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ncn4CCOc34)n[nH]c2c1
Show InChI InChI=1S/C21H17Cl2N5O4/c1-30-13-8-14(31-2)17(23)15(16(13)22)10-3-4-11-12(7-10)26-27-19(11)25-20(29)18-21-28(9-24-18)5-6-32-21/h3-4,7-9H,5-6H2,1-2H3,(H2,25,26,27,29)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434560
PNG
(US10562900, Example 44)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434562
PNG
(US10562900, Example 46)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H29F2N5O3/c1-28(2)15-35(12-11-31-28)18-8-5-16(6-9-18)27(36)32-26-19-10-7-17(13-20(19)33-34-26)23-24(29)21(37-3)14-22(38-4)25(23)30/h5-10,13-14,31H,11-12,15H2,1-4H3,(H2,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434565
PNG
(US10562900, Example 55)
Show SMILES COc1cc(OC)c(F)c(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434567
PNG
(US10562900, Example 64 | US10562900, Example 66)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-14-12-35(13-15(2)30-14)17-7-5-16(6-8-17)27(36)32-26-18-9-10-19(31-25(18)33-34-26)22-23(28)20(37-3)11-21(38-4)24(22)29/h5-11,14-15,30H,12-13H2,1-4H3,(H2,31,32,33,34,36)/t14-,15+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434567
PNG
(US10562900, Example 64 | US10562900, Example 66)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-14-12-35(13-15(2)30-14)17-7-5-16(6-8-17)27(36)32-26-18-9-10-19(31-25(18)33-34-26)22-23(28)20(37-3)11-21(38-4)24(22)29/h5-11,14-15,30H,12-13H2,1-4H3,(H2,31,32,33,34,36)/t14-,15+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434568
PNG
(US10562900, Example 65)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C27H28Cl2N6O3/c1-4-34-11-13-35(14-12-34)17-7-5-16(6-8-17)27(36)31-26-18-9-10-19(30-25(18)32-33-26)22-23(28)20(37-2)15-21(38-3)24(22)29/h5-10,15H,4,11-14H2,1-3H3,(H2,30,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434573
PNG
(US10562900, Example 70)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2n1
Show InChI InChI=1S/C25H23Cl2N5O4/c1-34-18-13-19(35-2)22(27)20(21(18)26)17-8-7-16-23(28-17)30-31-24(16)29-25(33)14-3-5-15(6-4-14)32-9-11-36-12-10-32/h3-8,13H,9-12H2,1-2H3,(H2,28,29,30,31,33)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434573
PNG
(US10562900, Example 70)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2n1
Show InChI InChI=1S/C25H23Cl2N5O4/c1-34-18-13-19(35-2)22(27)20(21(18)26)17-8-7-16-23(28-17)30-31-24(16)29-25(33)14-3-5-15(6-4-14)32-9-11-36-12-10-32/h3-8,13H,9-12H2,1-2H3,(H2,28,29,30,31,33)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434574
PNG
(US10562900, Example 71)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434579
PNG
(US10562900, Example 86)
Show SMILES CCN1CCN(CC1)c1ccc(cn1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O3/c1-4-34-9-11-35(12-10-34)20-8-5-15(14-29-20)26(36)31-25-16-6-7-17(30-24(16)32-33-25)21-22(27)18(37-2)13-19(38-3)23(21)28/h5-8,13-14H,4,9-12H2,1-3H3,(H2,30,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434582
PNG
(US10562900, Example 89)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCC(CC3)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C29H29Cl2N5O3/c1-38-22-15-23(39-2)26(31)24(25(22)30)21-10-9-20-27(32-21)34-35-28(20)33-29(37)18-5-7-19(8-6-18)36-13-11-17(12-14-36)16-3-4-16/h5-10,15-17H,3-4,11-14H2,1-2H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434583
PNG
(US10562900, Example 90)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)C(C)[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C29H31Cl2N5O3/c1-15-13-36(14-16(2)17(15)3)19-8-6-18(7-9-19)29(37)33-28-20-10-11-21(32-27(20)34-35-28)24-25(30)22(38-4)12-23(39-5)26(24)31/h6-12,15-17H,13-14H2,1-5H3,(H2,32,33,34,35,37)/t15-,16+,17?
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434584
PNG
(US10562900, Example 91)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(F)c3)n[nH]c2n1
Show InChI InChI=1S/C27H27Cl2FN6O3/c1-27(2)13-36(10-9-31-27)18-8-5-14(11-16(18)30)26(37)33-25-15-6-7-17(32-24(15)34-35-25)21-22(28)19(38-3)12-20(39-4)23(21)29/h5-8,11-12,31H,9-10,13H2,1-4H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434585
PNG
(US10562900, Example 92)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3cnc(nc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C24H24Cl2N8O3/c1-33-6-8-34(9-7-33)24-27-11-13(12-28-24)23(35)30-22-14-4-5-15(29-21(14)31-32-22)18-19(25)16(36-2)10-17(37-3)20(18)26/h4-5,10-12H,6-9H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434589
PNG
(US10562900, Example 96)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4cnc(nc4)N4CCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C25H25F2N7O3/c1-33-6-8-34(9-7-33)25-28-12-15(13-29-25)24(35)30-23-16-5-4-14(10-17(16)31-32-23)20-21(26)18(36-2)11-19(37-3)22(20)27/h4-5,10-13H,6-9H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434590
PNG
(US10562900, Example 97)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(OC)c3)n[nH]c2c1
Show InChI InChI=1S/C29H31F2N5O4/c1-29(2)15-36(11-10-32-29)20-9-7-17(13-21(20)38-3)28(37)33-27-18-8-6-16(12-19(18)34-35-27)24-25(30)22(39-4)14-23(40-5)26(24)31/h6-9,12-14,32H,10-11,15H2,1-5H3,(H2,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434536
PNG
(US10562900, Example 14)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434540
PNG
(US10562900, Example 18)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H29Cl2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434551
PNG
(US10562900, Example 29)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H31N5O3/c1-17-15-33(16-18(2)29-17)22-8-5-19(6-9-22)28(34)30-27-25-10-7-20(13-26(25)31-32-27)21-11-23(35-3)14-24(12-21)36-4/h5-14,17-18,29H,15-16H2,1-4H3,(H2,30,31,32,34)/t17-,18+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434552
PNG
(US10562900, Example 30)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(=O)C(C)(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C31H33Cl2N5O4/c1-31(2,3)30(40)38-14-12-37(13-15-38)20-9-6-18(7-10-20)29(39)34-28-21-11-8-19(16-22(21)35-36-28)25-26(32)23(41-4)17-24(42-5)27(25)33/h6-11,16-17H,12-15H2,1-5H3,(H2,34,35,36,39)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434555
PNG
(US10562900, Example 33)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(CCC(=O)N(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H26Cl2N4O4/c1-33(2)22(34)12-7-15-5-8-16(9-6-15)27(35)30-26-18-11-10-17(13-19(18)31-32-26)23-24(28)20(36-3)14-21(37-4)25(23)29/h5-6,8-11,13-14H,7,12H2,1-4H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434555
PNG
(US10562900, Example 33)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(CCC(=O)N(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H26Cl2N4O4/c1-33(2)22(34)12-7-15-5-8-16(9-6-15)27(35)30-26-18-11-10-17(13-19(18)31-32-26)23-24(28)20(36-3)14-21(37-4)25(23)29/h5-6,8-11,13-14H,7,12H2,1-4H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434560
PNG
(US10562900, Example 44)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434568
PNG
(US10562900, Example 65)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C27H28Cl2N6O3/c1-4-34-11-13-35(14-12-34)17-7-5-16(6-8-17)27(36)31-26-18-9-10-19(30-25(18)32-33-26)22-23(28)20(37-2)15-21(38-3)24(22)29/h5-10,15H,4,11-14H2,1-3H3,(H2,30,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434570
PNG
(US10562900, Example 67)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(CC4)N(C)C)n[nH]c3n2)c1Cl
Show InChI InChI=1S/C28H30Cl2N6O3/c1-35(2)17-11-13-36(14-12-17)18-7-5-16(6-8-18)28(37)32-27-19-9-10-20(31-26(19)33-34-27)23-24(29)21(38-3)15-22(39-4)25(23)30/h5-10,15,17H,11-14H2,1-4H3,(H2,31,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434574
PNG
(US10562900, Example 71)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434581
PNG
(US10562900, Example 88)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCN(CC3)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C27H27Cl2N7O3/c1-38-19-13-20(39-2)24(29)22(23(19)28)18-7-6-17-25(31-18)33-34-26(17)32-27(37)15-3-8-21(30-14-15)36-11-9-35(10-12-36)16-4-5-16/h3,6-8,13-14,16H,4-5,9-12H2,1-2H3,(H2,31,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434582
PNG
(US10562900, Example 89)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCC(CC3)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C29H29Cl2N5O3/c1-38-22-15-23(39-2)26(31)24(25(22)30)21-10-9-20-27(32-21)34-35-28(20)33-29(37)18-5-7-19(8-6-18)36-13-11-17(12-14-36)16-3-4-16/h5-10,15-17H,3-4,11-14H2,1-2H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434583
PNG
(US10562900, Example 90)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)C(C)[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C29H31Cl2N5O3/c1-15-13-36(14-16(2)17(15)3)19-8-6-18(7-9-19)29(37)33-28-20-10-11-21(32-27(20)34-35-28)24-25(30)22(38-4)12-23(39-5)26(24)31/h6-12,15-17H,13-14H2,1-5H3,(H2,32,33,34,35,37)/t15-,16+,17?
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434587
PNG
(US10562900, Example 94)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29F2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434588
PNG
(US10562900, Example 95)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C28H29F2N5O3/c1-34-11-4-12-35(14-13-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434543
PNG
(US10562900, Example 21)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cn4)N4C[C@H](C)N[C@H](C)C4)n[nH]c3c2)c1Cl
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434543
PNG
(US10562900, Example 21)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cn4)N4C[C@H](C)N[C@H](C)C4)n[nH]c3c2)c1Cl
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434544
PNG
(US10562900, Example 22)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-28(2)15-35(12-11-31-28)18-8-5-16(6-9-18)27(36)32-26-19-10-7-17(13-20(19)33-34-26)23-24(29)21(37-3)14-22(38-4)25(23)30/h5-10,13-14,31H,11-12,15H2,1-4H3,(H2,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434545
PNG
(US10562900, Example 23)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4cccc(c4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-9-11-34(12-10-33)18-6-4-5-17(13-18)27(35)30-26-19-8-7-16(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-8,13-15H,9-12H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434550
PNG
(US10562900, Example 28)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NC(=O)CN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C26H25Cl2N5O4/c1-33(2)13-21(34)29-16-8-5-14(6-9-16)26(35)30-25-17-10-7-15(11-18(17)31-32-25)22-23(27)19(36-3)12-20(37-4)24(22)28/h5-12H,13H2,1-4H3,(H,29,34)(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434551
PNG
(US10562900, Example 29)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H31N5O3/c1-17-15-33(16-18(2)29-17)22-8-5-19(6-9-22)28(34)30-27-25-10-7-20(13-26(25)31-32-27)21-11-23(35-3)14-24(12-21)36-4/h5-14,17-18,29H,15-16H2,1-4H3,(H2,30,31,32,34)/t17-,18+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434552
PNG
(US10562900, Example 30)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(=O)C(C)(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C31H33Cl2N5O4/c1-31(2,3)30(40)38-14-12-37(13-15-38)20-9-6-18(7-10-20)29(39)34-28-21-11-8-19(16-22(21)35-36-28)25-26(32)23(41-4)17-24(42-5)27(25)33/h6-11,16-17H,12-15H2,1-5H3,(H2,34,35,36,39)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434566
PNG
(US10562900, Example 63)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C26H26Cl2N6O3/c1-33-10-12-34(13-11-33)16-6-4-15(5-7-16)26(35)30-25-17-8-9-18(29-24(17)31-32-25)21-22(27)19(36-2)14-20(37-3)23(21)28/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434566
PNG
(US10562900, Example 63)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C26H26Cl2N6O3/c1-33-10-12-34(13-11-33)16-6-4-15(5-7-16)26(35)30-25-17-8-9-18(29-24(17)31-32-25)21-22(27)19(36-2)14-20(37-3)23(21)28/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434570
PNG
(US10562900, Example 67)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(CC4)N(C)C)n[nH]c3n2)c1Cl
Show InChI InChI=1S/C28H30Cl2N6O3/c1-35(2)17-11-13-36(14-12-17)18-7-5-16(6-8-18)28(37)32-27-19-9-10-20(31-26(19)33-34-27)23-24(29)21(38-3)15-22(39-4)25(23)30/h5-10,15,17H,11-14H2,1-4H3,(H2,31,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434576
PNG
(US10562900, Example 73)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CC4(CNC4)C3)n[nH]c2n1
Show InChI InChI=1S/C26H24Cl2N6O3/c1-36-18-9-19(37-2)22(28)20(21(18)27)17-8-7-16-23(30-17)32-33-24(16)31-25(35)14-3-5-15(6-4-14)34-12-26(13-34)10-29-11-26/h3-9,29H,10-13H2,1-2H3,(H2,30,31,32,33,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434588
PNG
(US10562900, Example 95)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C28H29F2N5O3/c1-34-11-4-12-35(14-13-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434592
PNG
(US10562900, Example 99)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CC(C)(C)CC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C30H33Cl2N5O3/c1-29(2)14-30(3,4)16-37(15-29)18-9-7-17(8-10-18)28(38)34-27-19-11-12-20(33-26(19)35-36-27)23-24(31)21(39-5)13-22(40-6)25(23)32/h7-13H,14-16H2,1-6H3,(H2,33,34,35,36,38)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434593
PNG
(US10562900, Example 100)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(C4)N(C)C)n[nH]c3n2)c1Cl
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434537
PNG
(US10562900, Example 15)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434538
PNG
(US10562900, Example 16)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434539
PNG
(US10562900, Example 17)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2c1
Show InChI InChI=1S/C26H24Cl2N4O4/c1-34-20-14-21(35-2)24(28)22(23(20)27)16-5-8-18-19(13-16)30-31-25(18)29-26(33)15-3-6-17(7-4-15)32-9-11-36-12-10-32/h3-8,13-14H,9-12H2,1-2H3,(H2,29,30,31,33)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434540
PNG
(US10562900, Example 18)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H29Cl2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434542
PNG
(US10562900, Example 20)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NCCN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C26H27Cl2N5O3/c1-33(2)12-11-29-17-8-5-15(6-9-17)26(34)30-25-18-10-7-16(13-19(18)31-32-25)22-23(27)20(35-3)14-21(36-4)24(22)28/h5-10,13-14,29H,11-12H2,1-4H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434542
PNG
(US10562900, Example 20)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NCCN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C26H27Cl2N5O3/c1-33(2)12-11-29-17-8-5-15(6-9-17)26(34)30-25-18-10-7-16(13-19(18)31-32-25)22-23(27)20(35-3)14-21(36-4)24(22)28/h5-10,13-14,29H,11-12H2,1-4H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434544
PNG
(US10562900, Example 22)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-28(2)15-35(12-11-31-28)18-8-5-16(6-9-18)27(36)32-26-19-10-7-17(13-20(19)33-34-26)23-24(29)21(37-3)14-22(38-4)25(23)30/h5-10,13-14,31H,11-12,15H2,1-4H3,(H2,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434547
PNG
(US10562900, Example 25)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNCC3)n[nH]c2c1
Show InChI InChI=1S/C26H25Cl2N5O3/c1-35-20-14-21(36-2)24(28)22(23(20)27)16-5-8-18-19(13-16)31-32-25(18)30-26(34)15-3-6-17(7-4-15)33-11-9-29-10-12-33/h3-8,13-14,29H,9-12H2,1-2H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434549
PNG
(US10562900, Example 27)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(CCO)CC3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O4/c1-38-22-16-23(39-2)26(30)24(25(22)29)18-5-8-20-21(15-18)32-33-27(20)31-28(37)17-3-6-19(7-4-17)35-11-9-34(10-12-35)13-14-36/h3-8,15-16,36H,9-14H2,1-2H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434563
PNG
(US10562900, Example 47)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H29F2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434571
PNG
(US10562900, Example 68)
Show SMILES COc1cc(OC)cc(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H30N6O3/c1-16-14-33(15-17(2)28-16)20-7-5-18(6-8-20)27(34)30-26-23-9-10-24(29-25(23)31-32-26)19-11-21(35-3)13-22(12-19)36-4/h5-13,16-17,28H,14-15H2,1-4H3,(H2,29,30,31,32,34)/t16-,17+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434572
PNG
(US10562900, Example 69)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccncc4)n[nH]c3n2)c1Cl
Show InChI InChI=1S/C20H15Cl2N5O3/c1-29-13-9-14(30-2)17(22)15(16(13)21)12-4-3-11-18(24-12)26-27-19(11)25-20(28)10-5-7-23-8-6-10/h3-9H,1-2H3,(H2,24,25,26,27,28)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434572
PNG
(US10562900, Example 69)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccncc4)n[nH]c3n2)c1Cl
Show InChI InChI=1S/C20H15Cl2N5O3/c1-29-13-9-14(30-2)17(22)15(16(13)21)12-4-3-11-18(24-12)26-27-19(11)25-20(28)10-5-7-23-8-6-10/h3-9H,1-2H3,(H2,24,25,26,27,28)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434577
PNG
(US10562900, Example 83)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNCC3)n[nH]c2n1
Show InChI InChI=1S/C25H24Cl2N6O3/c1-35-18-13-19(36-2)22(27)20(21(18)26)17-8-7-16-23(29-17)31-32-24(16)30-25(34)14-3-5-15(6-4-14)33-11-9-28-10-12-33/h3-8,13,28H,9-12H2,1-2H3,(H2,29,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434580
PNG
(US10562900, Example 87)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCNC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C26H27Cl2N7O3/c1-26(2)13-35(10-9-30-26)19-8-5-14(12-29-19)25(36)32-24-15-6-7-16(31-23(15)33-34-24)20-21(27)17(37-3)11-18(38-4)22(20)28/h5-8,11-12,30H,9-10,13H2,1-4H3,(H2,31,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434586
PNG
(US10562900, Example 93)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCCCC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C27H26F2N4O3/c1-35-21-15-22(36-2)25(29)23(24(21)28)17-8-11-19-20(14-17)31-32-26(19)30-27(34)16-6-9-18(10-7-16)33-12-4-3-5-13-33/h6-11,14-15H,3-5,12-13H2,1-2H3,(H2,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434538
PNG
(US10562900, Example 16)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434539
PNG
(US10562900, Example 17)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2c1
Show InChI InChI=1S/C26H24Cl2N4O4/c1-34-20-14-21(35-2)24(28)22(23(20)27)16-5-8-18-19(13-16)30-31-25(18)29-26(33)15-3-6-17(7-4-15)32-9-11-36-12-10-32/h3-8,13-14H,9-12H2,1-2H3,(H2,29,30,31,33)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434540
PNG
(US10562900, Example 18)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H29Cl2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434548
PNG
(US10562900, Example 26)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NCCCN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H29Cl2N5O3/c1-34(2)13-5-12-30-18-9-6-16(7-10-18)27(35)31-26-19-11-8-17(14-20(19)32-33-26)23-24(28)21(36-3)15-22(37-4)25(23)29/h6-11,14-15,30H,5,12-13H2,1-4H3,(H2,31,32,33,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434556
PNG
(US10562900, Example 34)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(CN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C25H24Cl2N4O3/c1-31(2)13-14-5-7-15(8-6-14)25(32)28-24-17-10-9-16(11-18(17)29-30-24)21-22(26)19(33-3)12-20(34-4)23(21)27/h5-12H,13H2,1-4H3,(H2,28,29,30,32)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434557
PNG
(US10562900, Example 35)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C24H22Cl2N4O3/c1-30(2)15-8-5-13(6-9-15)24(31)27-23-16-10-7-14(11-17(16)28-29-23)20-21(25)18(32-3)12-19(33-4)22(20)26/h5-12H,1-4H3,(H2,27,28,29,31)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434557
PNG
(US10562900, Example 35)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N(C)C)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C24H22Cl2N4O3/c1-30(2)15-8-5-13(6-9-15)24(31)27-23-16-10-7-14(11-17(16)28-29-23)20-21(25)18(32-3)12-19(33-4)22(20)26/h5-12H,1-4H3,(H2,27,28,29,31)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434578
PNG
(US10562900, Example 85)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-33-8-10-34(11-9-33)19-7-4-14(13-28-19)25(35)30-24-15-5-6-16(29-23(15)31-32-24)20-21(26)17(36-2)12-18(37-3)22(20)27/h4-7,12-13H,8-11H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434578
PNG
(US10562900, Example 85)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C25H25Cl2N7O3/c1-33-8-10-34(11-9-33)19-7-4-14(13-28-19)25(35)30-24-15-5-6-16(29-23(15)31-32-24)20-21(26)17(36-2)12-18(37-3)22(20)27/h4-7,12-13H,8-11H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434579
PNG
(US10562900, Example 86)
Show SMILES CCN1CCN(CC1)c1ccc(cn1)C(=O)Nc1n[nH]c2nc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C26H27Cl2N7O3/c1-4-34-9-11-35(12-10-34)20-8-5-15(14-29-20)26(36)31-25-16-6-7-17(30-24(16)32-33-25)21-22(27)18(37-2)13-19(38-3)23(21)28/h5-8,13-14H,4,9-12H2,1-3H3,(H2,30,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434584
PNG
(US10562900, Example 91)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(F)c3)n[nH]c2n1
Show InChI InChI=1S/C27H27Cl2FN6O3/c1-27(2)13-36(10-9-31-27)18-8-5-14(11-16(18)30)26(37)33-25-15-6-7-17(32-24(15)34-35-25)21-22(28)19(38-3)12-20(39-4)23(21)29/h5-8,11-12,31H,9-10,13H2,1-4H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434585
PNG
(US10562900, Example 92)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3cnc(nc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C24H24Cl2N8O3/c1-33-6-8-34(9-7-33)24-27-11-13(12-28-24)23(35)30-22-14-4-5-15(29-21(14)31-32-22)18-19(25)16(36-2)10-17(37-3)20(18)26/h4-5,10-12H,6-9H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434590
PNG
(US10562900, Example 97)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(OC)c3)n[nH]c2c1
Show InChI InChI=1S/C29H31F2N5O4/c1-29(2)15-36(11-10-32-29)20-9-7-17(13-21(20)38-3)28(37)33-27-18-8-6-16(12-19(18)34-35-27)24-25(30)22(39-4)14-23(40-5)26(24)31/h6-9,12-14,32H,10-11,15H2,1-5H3,(H2,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434545
PNG
(US10562900, Example 23)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4cccc(c4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-9-11-34(12-10-33)18-6-4-5-17(13-18)27(35)30-26-19-8-7-16(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-8,13-15H,9-12H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434554
PNG
(US10562900, Example 32)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ncn4CCOc34)n[nH]c2c1
Show InChI InChI=1S/C21H17Cl2N5O4/c1-30-13-8-14(31-2)17(23)15(16(13)22)10-3-4-11-12(7-10)26-27-19(11)25-20(29)18-21-28(9-24-18)5-6-32-21/h3-4,7-9H,5-6H2,1-2H3,(H2,25,26,27,29)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434561
PNG
(US10562900, Example 45)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C27H27F2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434562
PNG
(US10562900, Example 46)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2c1
Show InChI InChI=1S/C28H29F2N5O3/c1-28(2)15-35(12-11-31-28)18-8-5-16(6-9-18)27(36)32-26-19-10-7-17(13-20(19)33-34-26)23-24(29)21(37-3)14-22(38-4)25(23)30/h5-10,13-14,31H,11-12,15H2,1-4H3,(H2,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434563
PNG
(US10562900, Example 47)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(F)c(OC)cc(OC)c1F
Show InChI InChI=1S/C28H29F2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434564
PNG
(US10562900, Example 48)
Show SMILES COc1cc(OC)c(F)c(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C26H27FN6O3/c1-32-10-12-33(13-11-32)17-6-4-16(5-7-17)26(34)29-25-19-8-9-21(28-24(19)30-31-25)20-14-18(35-2)15-22(36-3)23(20)27/h4-9,14-15H,10-13H2,1-3H3,(H2,28,29,30,31,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434564
PNG
(US10562900, Example 48)
Show SMILES COc1cc(OC)c(F)c(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C26H27FN6O3/c1-32-10-12-33(13-11-32)17-6-4-16(5-7-17)26(34)29-25-19-8-9-21(28-24(19)30-31-25)20-14-18(35-2)15-22(36-3)23(20)27/h4-9,14-15H,10-13H2,1-3H3,(H2,28,29,30,31,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434567
PNG
(US10562900, Example 64 | US10562900, Example 66)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-14-12-35(13-15(2)30-14)17-7-5-16(6-8-17)27(36)32-26-18-9-10-19(31-25(18)33-34-26)22-23(28)20(37-3)11-21(38-4)24(22)29/h5-11,14-15,30H,12-13H2,1-4H3,(H2,31,32,33,34,36)/t14-,15+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434575
PNG
(US10562900, Example 72)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-27(2)14-35(12-11-30-27)16-7-5-15(6-8-16)26(36)32-25-17-9-10-18(31-24(17)33-34-25)21-22(28)19(37-3)13-20(38-4)23(21)29/h5-10,13,30H,11-12,14H2,1-4H3,(H2,31,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434575
PNG
(US10562900, Example 72)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-27(2)14-35(12-11-30-27)16-7-5-15(6-8-16)26(36)32-25-17-9-10-18(31-24(17)33-34-25)21-22(28)19(37-3)13-20(38-4)23(21)29/h5-10,13,30H,11-12,14H2,1-4H3,(H2,31,32,33,34,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434576
PNG
(US10562900, Example 73)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CC4(CNC4)C3)n[nH]c2n1
Show InChI InChI=1S/C26H24Cl2N6O3/c1-36-18-9-19(37-2)22(28)20(21(18)27)17-8-7-16-23(30-17)32-33-24(16)31-25(35)14-3-5-15(6-4-14)34-12-26(13-34)10-29-11-26/h3-9,29H,10-13H2,1-2H3,(H2,30,31,32,33,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434577
PNG
(US10562900, Example 83)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNCC3)n[nH]c2n1
Show InChI InChI=1S/C25H24Cl2N6O3/c1-35-18-13-19(36-2)22(27)20(21(18)26)17-8-7-16-23(29-17)31-32-24(16)30-25(34)14-3-5-15(6-4-14)33-11-9-28-10-12-33/h3-8,13,28H,9-12H2,1-2H3,(H2,29,30,31,32,34)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434587
PNG
(US10562900, Example 94)
Show SMILES COc1cc(OC)c(F)c(c1F)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29F2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434591
PNG
(US10562900, Example 98)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(C4)N(C)C)n[nH]c3c2)c1F
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434593
PNG
(US10562900, Example 100)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCC(C4)N(C)C)n[nH]c3n2)c1Cl
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434594
PNG
(US10562900, Example 101)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(N4CCNC(C)(C)C4)c(OC)c3)n[nH]c2n1
Show InChI InChI=1S/C28H30Cl2N6O4/c1-28(2)14-36(11-10-31-28)18-9-6-15(12-19(18)38-3)27(37)33-26-16-7-8-17(32-25(16)34-35-26)22-23(29)20(39-4)13-21(40-5)24(22)30/h6-9,12-13,31H,10-11,14H2,1-5H3,(H2,32,33,34,35,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434539
PNG
(US10562900, Example 17)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2c1
Show InChI InChI=1S/C26H24Cl2N4O4/c1-34-20-14-21(35-2)24(28)22(23(20)27)16-5-8-18-19(13-16)30-31-25(18)29-26(33)15-3-6-17(7-4-15)32-9-11-36-12-10-32/h3-8,13-14H,9-12H2,1-2H3,(H2,29,30,31,33)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434548
PNG
(US10562900, Example 26)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(NCCCN(C)C)cc4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H29Cl2N5O3/c1-34(2)13-5-12-30-18-9-6-16(7-10-18)27(35)31-26-19-11-8-17(14-20(19)32-33-26)23-24(28)21(36-3)15-22(37-4)25(23)29/h6-11,14-15,30H,5,12-13H2,1-4H3,(H2,31,32,33,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434553
PNG
(US10562900, Example 31)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3cnn(CCO)c3)n[nH]c2c1
Show InChI InChI=1S/C21H19Cl2N5O4/c1-31-15-8-16(32-2)19(23)17(18(15)22)11-3-4-13-14(7-11)26-27-20(13)25-21(30)12-9-24-28(10-12)5-6-29/h3-4,7-10,29H,5-6H2,1-2H3,(H2,25,26,27,30)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434565
PNG
(US10562900, Example 55)
Show SMILES COc1cc(OC)c(F)c(c1)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434566
PNG
(US10562900, Example 63)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)n[nH]c2n1
Show InChI InChI=1S/C26H26Cl2N6O3/c1-33-10-12-34(13-11-33)16-6-4-15(5-7-16)26(35)30-25-17-8-9-18(29-24(17)31-32-25)21-22(27)19(36-2)14-20(37-3)23(21)28/h4-9,14H,10-13H2,1-3H3,(H2,29,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434567
PNG
(US10562900, Example 64 | US10562900, Example 66)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2n1
Show InChI InChI=1S/C27H28Cl2N6O3/c1-14-12-35(13-15(2)30-14)17-7-5-16(6-8-17)27(36)32-26-18-9-10-19(31-25(18)33-34-26)22-23(28)20(37-3)11-21(38-4)24(22)29/h5-11,14-15,30H,12-13H2,1-4H3,(H2,31,32,33,34,36)/t14-,15+
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM434581
PNG
(US10562900, Example 88)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(nc3)N3CCN(CC3)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C27H27Cl2N7O3/c1-38-19-13-20(39-2)24(29)22(23(19)28)18-7-6-17-25(31-18)33-34-26(17)32-27(37)15-3-8-21(30-14-15)36-11-9-35(10-12-36)16-4-5-16/h3,6-8,13-14,16H,4-5,9-12H2,1-2H3,(H2,31,32,33,34,37)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434589
PNG
(US10562900, Example 96)
Show SMILES COc1cc(OC)c(F)c(-c2ccc3c(NC(=O)c4cnc(nc4)N4CCN(C)CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C25H25F2N7O3/c1-33-6-8-34(9-7-33)25-28-12-15(13-29-25)24(35)30-23-16-5-4-14(10-17(16)31-32-23)20-21(26)18(36-2)11-19(37-3)22(20)27/h4-5,10-13H,6-9H2,1-3H3,(H2,30,31,32,35)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM434592
PNG
(US10562900, Example 99)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CC(C)(C)CC(C)(C)C3)n[nH]c2n1
Show InChI InChI=1S/C30H33Cl2N5O3/c1-29(2)14-30(3,4)16-37(15-29)18-9-7-17(8-10-18)28(38)34-27-19-11-12-20(33-26(19)35-36-27)23-24(31)21(39-5)13-22(40-6)25(23)32/h7-13H,14-16H2,1-6H3,(H2,33,34,35,36,38)
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n/an/a<100n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434540
PNG
(US10562900, Example 18)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(ccc12)-c1c(Cl)c(OC)cc(OC)c1Cl
Show InChI InChI=1S/C28H29Cl2N5O3/c1-4-34-11-13-35(14-12-34)19-8-5-17(6-9-19)28(36)31-27-20-10-7-18(15-21(20)32-33-27)24-25(29)22(37-2)16-23(38-3)26(24)30/h5-10,15-16H,4,11-14H2,1-3H3,(H2,31,32,33,36)
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n/an/a<200n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434537
PNG
(US10562900, Example 15)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C27H27Cl2N5O3/c1-33-10-12-34(13-11-33)18-7-4-16(5-8-18)27(35)30-26-19-9-6-17(14-20(19)31-32-26)23-24(28)21(36-2)15-22(37-3)25(23)29/h4-9,14-15H,10-13H2,1-3H3,(H2,30,31,32,35)
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n/an/a<200n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434536
PNG
(US10562900, Example 14)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]c2c1
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n/an/a<200n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434538
PNG
(US10562900, Example 16)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(CN4CCN(C)CC4)cc3)n[nH]c2c1
Show InChI InChI=1S/C28H29Cl2N5O3/c1-34-10-12-35(13-11-34)16-17-4-6-18(7-5-17)28(36)31-27-20-9-8-19(14-21(20)32-33-27)24-25(29)22(37-2)15-23(38-3)26(24)30/h4-9,14-15H,10-13,16H2,1-3H3,(H2,31,32,33,36)
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n/an/a 600n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434539
PNG
(US10562900, Example 17)
Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCOCC3)n[nH]c2c1
Show InChI InChI=1S/C26H24Cl2N4O4/c1-34-20-14-21(35-2)24(28)22(23(20)27)16-5-8-18-19(13-16)30-31-25(18)29-26(33)15-3-6-17(7-4-15)32-9-11-36-12-10-32/h3-8,13-14H,9-12H2,1-2H3,(H2,29,30,31,33)
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n/an/a 600n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM434541
PNG
(US10562900, Example 19 | US10562900, Example 36)
Show SMILES COc1cc(OC)c(Cl)c(-c2ccc3c(NC(=O)c4ccc(cc4)N4CCN(CC4)C(C)=O)n[nH]c3c2)c1Cl
Show InChI InChI=1S/C28H27Cl2N5O4/c1-16(36)34-10-12-35(13-11-34)19-7-4-17(5-8-19)28(37)31-27-20-9-6-18(14-21(20)32-33-27)24-25(29)22(38-2)15-23(39-3)26(24)30/h4-9,14-15H,10-13H2,1-3H3,(H2,31,32,33,37)
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n/an/a 600n/an/an/an/an/an/a



Shanghai Haihe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica, Chinese Academy of Sciences

US Patent


Assay Description
The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...


US Patent US10562900 (2020)


BindingDB Entry DOI: 10.7270/Q21G0PNJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%