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Patent code US9321766

Compile Data Set for Download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM223589
PNG
(US9321766, 17)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)-n1ccc(C)c(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C25H24N6O3/c1-15-7-11-31(19-5-3-18(4-6-19)28-23(32)22-16(2)9-12-34-22)24(33)21(15)30-10-8-20-17(14-30)13-27-25(26)29-20/h3-7,9,11-13H,8,10,14H2,1-2H3,(H,28,32)(H2,26,27,29)
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US Patent
n/an/a 29n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM223589
PNG
(US9321766, 17)
Show SMILES Cc1ccoc1C(=O)Nc1ccc(cc1)-n1ccc(C)c(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C25H24N6O3/c1-15-7-11-31(19-5-3-18(4-6-19)28-23(32)22-16(2)9-12-34-22)24(33)21(15)30-10-8-20-17(14-30)13-27-25(26)29-20/h3-7,9,11-13H,8,10,14H2,1-2H3,(H,28,32)(H2,26,27,29)
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US Patent
n/an/a 33n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFR3 kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 10 mM ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM223587
PNG
(US9321766, 4)
Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C23H27N5O/c1-15-9-12-28(18-7-5-17(6-8-18)23(2,3)4)21(29)20(15)27-11-10-19-16(14-27)13-25-22(24)26-19/h5-9,12-13H,10-11,14H2,1-4H3,(H2,24,25,26)
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n/an/a 86n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM223585
PNG
(US9321766, 2)
Show SMILES CC(C)(C)c1ccc(cc1)-n1cccc(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C22H25N5O/c1-22(2,3)16-6-8-17(9-7-16)27-11-4-5-19(20(27)28)26-12-10-18-15(14-26)13-24-21(23)25-18/h4-9,11,13H,10,12,14H2,1-3H3,(H2,23,24,25)
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n/an/a 286n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM223588
PNG
(US9321766, 14)
Show SMILES CN(C)c1cccc(c1)-n1ccc(C)c(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C21H24N6O/c1-14-7-10-27(17-6-4-5-16(11-17)25(2)3)20(28)19(14)26-9-8-18-15(13-26)12-23-21(22)24-18/h4-7,10-12H,8-9,13H2,1-3H3,(H2,22,23,24)
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n/an/a 327n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM223587
PNG
(US9321766, 4)
Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C23H27N5O/c1-15-9-12-28(18-7-5-17(6-8-18)23(2,3)4)21(29)20(15)27-11-10-19-16(14-27)13-25-22(24)26-19/h5-9,12-13H,10-11,14H2,1-4H3,(H2,24,25,26)
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n/an/a 381n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFR3 kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 10 mM ...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM223585
PNG
(US9321766, 2)
Show SMILES CC(C)(C)c1ccc(cc1)-n1cccc(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C22H25N5O/c1-22(2,3)16-6-8-17(9-7-16)27-11-4-5-19(20(27)28)26-12-10-18-15(14-26)13-24-21(23)25-18/h4-9,11,13H,10,12,14H2,1-3H3,(H2,23,24,25)
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n/an/a 655n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFR3 kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 10 mM ...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM223588
PNG
(US9321766, 14)
Show SMILES CN(C)c1cccc(c1)-n1ccc(C)c(N2CCc3nc(N)ncc3C2)c1=O
Show InChI InChI=1S/C21H24N6O/c1-14-7-10-27(17-6-4-5-16(11-17)25(2)3)20(28)19(14)26-9-8-18-15(13-26)12-23-21(22)24-18/h4-7,10-12H,8-9,13H2,1-3H3,(H2,22,23,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFR3 kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 10 mM ...


Citation and Details
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (human))
BDBM223586
PNG
(US9321766, 3)
Show SMILES Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C13H15N5O/c1-8-2-4-15-12(19)11(8)18-5-3-10-9(7-18)6-16-13(14)17-10/h2,4,6H,3,5,7H2,1H3,(H,15,19)(H2,14,16,17)
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n/an/a 3.89E+3n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical PDGFR3 kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in 10 mM ...


Citation and Details
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM223586
PNG
(US9321766, 3)
Show SMILES Cc1cc[nH]c(=O)c1N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C13H15N5O/c1-8-2-4-15-12(19)11(8)18-5-3-10-9(7-18)6-16-13(14)17-10/h2,4,6H,3,5,7H2,1H3,(H,15,19)(H2,14,16,17)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10 m...


Citation and Details
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%