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Found 19 Enz. Inhib. hit(s) with all data for entry = 50039730
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  11nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  114nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50: >1.87E+4nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50: >1.87E+4nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human PARP2 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human PARP1 using NAD+ as substrate after 90 mins by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294819(CHEMBL564157 | N-Cyclohexyl-4-((1R,2S,6R,7S)-3,5-d...)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50382971(CHEMBL2030486)
Affinity DataEC50:  2.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294816(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294813(CHEMBL560509 | N-Benzyl-4-((1R,2S,6R,7S)-3,5-dioxo...)
Affinity DataEC50:  2.00E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294836(4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataEC50:  200nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataEC50:  200nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50382969(CHEMBL2030485)
Affinity DataEC50: >2.50E+4nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294799(CHEMBL551249 | N-(4-Bromo-phenyl)-4-((1R,2S,6R,7S)...)
Affinity DataEC50:  1.00E+3nMAssay Description:Activity of N-terminus hexaHis-tagged human TNSK2 expressed in Escherichia coli BL21 (DE3) cells using biotinylated NAD+ as substrate after 90 mins b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed