Reaction Details Report a problem with these data
Target
Peptide deformylase, mitochondrial
Ligand
BDBM50121441
Substrate
n/a
Meas. Tech.
ChEMBL_154177 (CHEMBL762381)
IC50
>1000±n/a nM
Citation
 Smith, HK; Beckett, RP; Clements, JM; Doel, S; East, SP; Launchbury, SB; Pratt, LM; Spavold, ZM; Thomas, W; Todd, RS; Whittaker, M Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group. Bioorg Med Chem Lett 12:3595-9 (2002) [PubMed]  Article 
Target
Name:
Peptide deformylase, mitochondrial
Synonyms:
DEFM_HUMAN | PDF | PDF1A | Peptide deformylase mitochondrial | Peptide deformylase, mitochondrial | Polypeptide deformylase
Type:
PROTEIN
Mol. Mass.:
27023.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154318
Residue:
243
Sequence:
MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPPEPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPRQVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLACVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMKVND
  
Inhibitor
Name:
BDBM50121441
Synonyms:
(R)-2-(N-Hydroxycarbamimidoylmethyl)-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide | CHEMBL120392
Type:
Small organic molecule
Emp. Form.:
C16H32N4O3
Mol. Mass.:
328.4503
SMILES:
CCCCC(CC(=N)NO)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C
Structure:
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