BDBM13771 2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylpropanamido]adamantan-1-yl]methoxy}acetic acid::adamantane ether 25

SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@@H]1C[C@](COCC(O)=O)(C3)C2

InChI Key InChIKey=ONHLADOANHWPPY-AXWDGYAMSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 13771   

Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)
Affinity DataIC50:  110nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)
Affinity DataIC50: >1.00E+5nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)
Affinity DataIC50:  110nMAssay Description:Inhibition of 11beta-HSD1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Mus musculus (mouse))
Abbott Laboratories

LigandPNGBDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)
Affinity DataIC50:  4.50E+4nMAssay Description:The in Vitro 11beta-HSD2 dehydrogenase assays were developed using the cell lysates that had the full length human or mouse 11beta-HSD2 cDNA over exp...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

LigandPNGBDBM13771(2-{[(1R,3R,4S,7S)-4-[2-(4-chlorophenoxy)-2-methylp...)
Affinity DataIC50:  210nMAssay Description:Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed