BDBM50013808 CHEMBL3265265::US10323013, Compound 25
SMILES Oc1ccc2c3CCN(Cc3c(=O)oc2c1C1SCCCS1)C(=O)OCC=C
InChI Key InChIKey=DWSLMEUOGIKYLG-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50013808
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
US Patent
H. Lee Moffitt Cancer Center and Research Institute
US Patent
Affinity DataIC50: 1.62E+4nMAssay Description:All compounds were evaluated by FRET-suppression assay in side-by-side experiments using 21b as a control inhibitor (Table 2). Protection of the alde...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center and Research Institute
US Patent
H. Lee Moffitt Cancer Center and Research Institute
US Patent
Affinity DataIC50: 1.62E+4nMAssay Description:Inhibition of human recombinant puritin-His-tagged IRE-1 RNase expressed in SF21 cells using XBP-1 RNA stem loop as substrate incubated for 30 mins p...More data for this Ligand-Target Pair