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Found 1077 with Last Name = 'baldwin' and Initial = 'j'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041043((1-{(1S,2S,3R,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.0900nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041045((4S,6S)-4-Ethylamino-7,7-dioxo-6-propyl-4,5,6,7-te...)
Affinity DataKi:  0.140nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM197((2S)-N-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[(2S)-3-meth...)
Affinity DataKi:  0.150nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041023((1-{(1S,2S,3S,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.160nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041037((4S,6R)-4-Ethylamino-7,7-dioxo-6-propyl-4,5,6,7-te...)
Affinity DataKi:  0.170nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041035(CHEMBL269401 | N-{(1S,2R,3R,4S)-1-Benzyl-2,3-dihyd...)
Affinity DataKi:  0.180nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041032((1-{(1S,2R,3R,4S)-1-Benzyl-2,3-dihydroxy-4-[3-meth...)
Affinity DataKi:  0.190nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50318494(3-ethyl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,...)
Affinity DataKi:  0.25nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041027((4S,6S)-6-Ethyl-4-ethylamino-7,7-dioxo-4,5,6,7-tet...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  0.370nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  0.490nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041029((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.610nMAssay Description:Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017729(4-Ethylamino-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*...)
Affinity DataKi:  0.690nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041029((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.700nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041029((S)-4-Isobutylamino-7,7-dioxo-4,5,6,7-tetrahydro-7...)
Affinity DataKi:  0.700nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50021195(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Affinity DataKi:  0.770nMAssay Description:Evaluated for its ability to displace [3H]-clonidine from alpha-2 adrenergic receptor of calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50367851(CHEMBL1788291)
Affinity DataKi:  0.820nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation at 3 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016400(2,6-Dimethyl-4-(2-methylsulfanyl-3-nitro-phenyl)-1...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041048((4S,6R)-6-Ethyl-4-ethylamino-7,7-dioxo-4,5,6,7-tet...)
Affinity DataKi:  1nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]nitrendipine binding to L-type calcium channel dihydropyridine site of porcine cardiac sarcolemma membrane vesiclesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50021195(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Affinity DataKi:  1.10nMAssay Description:Compound was tested for inhibition of human plasma reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017728(7,7-Dioxo-4-propylamino-4,5,6,7-tetrahydro-7lambda...)
Affinity DataKi:  1.10nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50024220(7-Oxo-6,7-dihydro-5H-thieno[3,2-b]thiopyran-2-sulf...)
Affinity DataKi:  1.20nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50021196(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Affinity DataKi:  1.40nMAssay Description:Evaluated for its ability to displace [3H]-clonidine from alpha-2 adrenergic receptor of calf cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041033((4S,6S)-4-Amino-6-methyl-7,7-dioxo-4,5,6,7-tetrahy...)
Affinity DataKi:  1.5nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
LigandPNGBDBM50021196(2-Hydroxy-ethanesulfonic acid (1,3,4,5,6,11b-hexah...)
Affinity DataKi:  1.60nMAssay Description:Compound was tested for inhibition of hog kidney reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041026(CHEMBL10113 | N-{(1S,2S,3S,4S)-1-Benzyl-2,3-dihydr...)
Affinity DataKi:  1.70nMAssay Description:Compound was evaluated for the inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017726(4-Butylamino-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*...)
Affinity DataKi:  1.80nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50041041((4S,6S)-6-Methyl-4-methylamino-7,7-dioxo-4,5,6,7-t...)
Affinity DataKi:  1.90nMAssay Description:Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
TargetThymidylate synthase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50005210((2-Imino-1-methyl-1,2-dihydro-benzo[cd]indol-6-yl)...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the inhibitory constant of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50005186((1,5-Dimethyl-2-methylimino-1,2-dihydro-benzo[cd]i...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the inhibitory constant of human thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM10884((2S,4S)-4-(ethylamino)-2-methyl-1,1-dioxo-2H,3H,4H...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)More data for this Ligand-Target Pair
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227000(3-[4-((R)-1-furan-2-yl-2,2-dimethyl-propylamino)-1...)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017732(4-Methylamino-7,7-dioxo-4,5,6,7-tetrahydro-7lambda...)
Affinity DataKi:  2.30nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227005(3-{4-[(R)-1-(4,5-dimethyl-furan-2-yl)-2-methyl-pro...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50226999(2-hydroxy-N,N-dimethyl-3-{4-[(R)-1-(5-methyl-furan...)
Affinity DataKi:  3nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50024224(7,7-Dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50024221(4-Oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulf...)
Affinity DataKi:  3.60nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017731(4-Amino-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-th...)
Affinity DataKi:  3.70nMAssay Description:The equilibrium dissociation constant of the inhibitor-enzyme complex of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50226995(3-[4-((R)-2,2-dimethyl-1-phenyl-propylamino)-1-oxo...)
Affinity DataKi:  4nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50404821(CHEMBL306465)
Affinity DataKi:  4nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50018739(1,3,4,5,6,11b-Hexahydro-2H-11-thia-4a-aza-benzo[a]...)
Affinity DataKi:  4.30nMAssay Description:Affinity to alpha-2 adrenergic receptor by the displacement of [3H]-clonidine from calf cerebral cortex membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227003(3-[4-((R)-1-benzo[1,3]dioxol-5-yl-2,2-dimethyl-pro...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50227001(3-{4-[(R)-2,2-dimethyl-1-(5-methyl-furan-2-yl)-pro...)
Affinity DataKi:  5nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50226996(2-hydroxy-N,N-dimethyl-3-[1-oxo-4-((R)-1-phenyl-pr...)
Affinity DataKi:  5nMAssay Description:Binding affinity to CXCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50452418(CHEMBL2092886)
Affinity DataKi:  6.20nMAssay Description:50% inhibitory concentration against human carbonic anhydrase II (HCA II) after pre-incubation for 4 min at 37 degree CMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50404823(CHEMBL63299)
Affinity DataKi:  6.30nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
TBA

Curated by ChEMBL
LigandPNGBDBM50404822(CHEMBL8982)
Affinity DataKi:  6.30nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50452418(CHEMBL2092886)
Affinity DataKi:  6.70nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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