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Found 572 with Last Name = 'fournié-zaluski' and Initial = 'mc'
TargetAminopeptidase B(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi: >0nMAssay Description:Inhibitory activity was measured on Aminopeptidase B using Arg p.NA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Sus scrofa)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078120((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for C+D stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Sus scrofa)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078122((R)-1-{[(S)-2-((S)-1-Carboxy-1-methyl-2-phenyl-eth...)
Affinity DataKi:  0nMAssay Description:Inhibitory activity was measured on Aminopeptidase using GluNA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM21653((2S)-2-[(2R)-2-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-...)
Affinity DataKi:  0.700nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407297(CHEMBL2052008)
Affinity DataKi:  0.700nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50083386(1-{[1-(2,3-Dicarboxy-pyrrolidine-1-carbonyl)-2-met...)
Affinity DataKi:  0.873nMAssay Description:Binding affinity against recombinant Aminopeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036831(6-Amino-2-mercapto-hexanoic acid | CHEMBL432852)
Affinity DataKi:  0.900nMAssay Description:Inhibition of arginylaminopeptidase (aminopeptidase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087104(C-{[3-Biphenyl-4-yl-2-(carboxymethyl-carbamoyl)-pr...)
Affinity DataKi:  0.940nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50105262(2-{3-[(1-Amino-ethyl)-hydroxy-phosphinoyl]-2-biphe...)
Affinity DataKi:  1.20nMAssay Description:Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  1.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50115846((S)-3-(1H-Indol-3-yl)-2-[(R)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  1.30nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087088((2S)-2-[(2S)-3-[(1-azaniumylethyl)(hydroxy)phospho...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  1.5nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.60nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.60nMAssay Description:In vivo inhibitory potency against neutral endopeptidase by displacement of [3H]-HACBOGly binding in mouse kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  1.70nMAssay Description:50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50105264(2-(2-Benzyl-3-hydroxycarbamoyl-propionylamino)-pro...)
Affinity DataKi:  1.70nMAssay Description:Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50115843((2S)-2-[(2R)-2-[(1R)-5-bromo-2,3-dihydro-1H-inden-...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50115842(2-(2-Indan-1-yl-3-mercapto-propionylamino)-3-(1H-i...)
Affinity DataKi:  1.80nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50405292(CHEMBL2079630)
Affinity DataKi:  1.80nMAssay Description:50% inhibitory activity against enkephalinase purified from rat kidney with [3H]D-Ala2-Leu-enkephalin (20 nM) as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.90nMAssay Description:Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087095(1-{[3-(4-Bromo-phenyl)-2-(1-carboxy-ethylcarbamoyl...)
Affinity DataKi:  1.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Mus musculus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50407299(CHEMBL2052007)
Affinity DataKi:  1.90nMAssay Description:Inhibitory potency against angiotensin converting enzyme by displacement of [3H]-trandolaprilate binding in mouse lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50105261(1-[2-(1-Benzyloxycarbonyl-2-phenyl-ethylcarbamoyl)...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087113((2S)-2-[(2S)-3-{[(S)-azaniumyl(phenyl)methyl](hydr...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50105263(2-{3-[(Amino-phenyl-methyl)-hydroxy-phosphinoyl]-2...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for inhibition of enkephalin degrading enzyme, neutral endopeptidase (NEP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087097(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087097(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087085((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087093(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078127(2-{3-[(1-Amino-3-phenyl-propyl)-hydroxy-phosphinoy...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087094((R,S,S)1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-4...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087084(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50115850((S)-3-(1H-Indol-3-yl)-2-[(S)-3-mercapto-2-((R)-5-m...)
Affinity DataKi:  2.70nMAssay Description:In vitro inhibition of Neutral endopeptidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50405292(CHEMBL2079630)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity against aminopeptidase using 10 nM of [3H]Leu-enkephalin as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087100((2S)-2-[(2S)-3-{[azaniumyl(phenyl)methyl](hydroxy)...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087089((2S)-2-[(2S)-3-{[(1S)-1-azaniumyl-2-phenylethyl](h...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087106((2S)-2-[(2S)-3-{[(1S)-1-azaniumylethyl](hydroxy)ph...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078134(2-{3-[(1-Amino-2-phenyl-ethyl)-hydroxy-phosphinoyl...)
Affinity DataKi:  2.90nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50105262(2-{3-[(1-Amino-ethyl)-hydroxy-phosphinoyl]-2-biphe...)
Affinity DataKi:  2.90nMAssay Description:Compound was evaluated for inhibition of enkephalin degrading enzyme, aminopeptidase N(APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Rattus norvegicus)
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50115837(2-[2-(5-Cyano-indan-1-yl)-3-mercapto-propionylamin...)
Affinity DataKi:  3nMAssay Description:In vitro inhibition of Angiotensin I converting enzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087114(C-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  3.10nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50083394(1-{[1-(1,2-Dicarboxy-ethylcarbamoyl)-2-methyl-buty...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity against recombinant Aminopeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50078131(2-{3-[(1-Amino-3-methyl-butyl)-hydroxy-phosphinoyl...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity was measured on pig kidney Aminopeptidase N (activity for A+B stereoisomer)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50087096(1-{[2-(1-Carboxy-2-phenyl-ethylcarbamoyl)-3-phenyl...)
Affinity DataKi:  3.20nMAssay Description:Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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