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Found 2846 with Last Name = 'ye' and Initial = 'g'
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550812(CHEMBL4756283)
Affinity DataKi:  0.00380nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50493145(CHEMBL2419149)
Affinity DataKi:  0.00420nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBone morphogenetic protein 1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458766(CHEMBL4212386)
Affinity DataKi:  0.00680nMAssay Description:Binding affinity to BMP1 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate preincubated for 3 hrs followed by subs...More data for this Ligand-Target Pair
TargetTolloid-like protein 1(Homo sapiens)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458766(CHEMBL4212386)
Affinity DataKi:  0.0310nMAssay Description:Binding affinity to TLL1 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate incubated for 3.5 hrs followed by subst...More data for this Ligand-Target Pair
TargetTolloid-like protein 2(Homo sapiens)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458766(CHEMBL4212386)
Affinity DataKi:  0.0390nMAssay Description:Binding affinity to TLL2 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate incubated for 3.5 hrs followed by subst...More data for this Ligand-Target Pair
TargetBone morphogenetic protein 1(Homo sapiens (Human))
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458771(CHEMBL4214046)
Affinity DataKi:  0.0400nMAssay Description:Binding affinity to BMP1 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate preincubated for 3 hrs followed by subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0410nMAssay Description:In vitro for inhibition of thrombin.More data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288406(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.0450nMAssay Description:Compound was tested in vitro for inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataKi:  0.0628nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.0709nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550832(CHEMBL4764086)
Affinity DataKi:  0.0867nMAssay Description:Displacement of [3H]DPCPX from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550813(CHEMBL1316674)
Affinity DataKi:  0.124nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(Mus musculus)
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.145nMAssay Description:Binding affinity to mouse adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288405(CHEMBL95940 | N-[(1-Dihydroxyboranyl-4-guanidino-b...)
Affinity DataKi:  0.160nMAssay Description:In vitro for inhibition of thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]DPCPX from adenosine A1 receptor in rat brain cortical membrane in presence of 100 uM GTPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTolloid-like protein 1(Homo sapiens)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458771(CHEMBL4214046)
Affinity DataKi:  0.240nMAssay Description:Binding affinity to TLL1 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate incubated for 3.5 hrs followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288414(1-(2-Acetylamino-3-phenyl-propionyl)-pyrrolidine-2...)
Affinity DataKi:  0.240nMAssay Description:In vitro for inhibition of thrombin.More data for this Ligand-Target Pair
TargetTolloid-like protein 2(Homo sapiens)
Glaxosmithkline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458771(CHEMBL4214046)
Affinity DataKi:  0.260nMAssay Description:Binding affinity to TLL2 (unknown origin) using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2 as substrate incubated for 3.5 hrs followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  0.295nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484029(CHEMBL1801258)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484039(CHEMBL1800087)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataKi:  0.348nMAssay Description:Displacement of [3H]CCPA from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550819(CHEMBL4796077)
Affinity DataKi:  0.348nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50315539(8-(2-Thioxo-7(3-propyl)-2-(2-furyl)thiazolo[4,3-e]...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]MSX2 from human adenosine receptor A2A expressed in HEK293 cell membranes incubated for 30 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50527135(CHEMBL4452072)
Affinity DataKi:  0.381nMAssay Description:Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in Sf9 cells using [2,8-3H]-AMP as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.400nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50308505(CHEMBL589080 | N-[5-pyridin-4-yl-4-(3,4,5-trimetho...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50308505(CHEMBL589080 | N-[5-pyridin-4-yl-4-(3,4,5-trimetho...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288409(CHEMBL99309 | N-[(5-Amino-1-dihydroxyboranyl-penty...)
Affinity DataKi:  0.420nMAssay Description:In vitro for inhibition of thrombin.More data for this Ligand-Target Pair
In DepthDetails Article
Target5'-nucleotidase(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50583394(CHEMBL5081267)
Affinity DataKi:  0.436nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50583393(CHEMBL5083600)
Affinity DataKi:  0.441nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50348176(CHEMBL1562432)
Affinity DataKi:  0.441nMAssay Description:Displacement of [3H]PSB-11 from human adenosine receptor A3 expressed in CHO cell membranes incubated for 60 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.490nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484045(CHEMBL1801257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484045(CHEMBL1801257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50583396(CHEMBL5074970)
Affinity DataKi:  0.511nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.529nMAssay Description:Displacement of [3H]CCPA from adenosine receptor A1 in rat brain cortex membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50550824(CHEMBL4797181)
Affinity DataKi:  0.529nMAssay Description:Displacement of [3H]CCPA from rat adenosine receptor A1 by radioligand competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Mus musculus)
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50079652((E)-1-[(R)-2-(2-Hydroxy-ethyl)-piperidin-1-yl]-3-(...)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to mouse adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50492052(CHEMBL2391834)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]CCPA from human adenosine receptor A1 expressed in CHO cell membranes incubated for 90 mins by radioligand competition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50308506(3-(4-aminophenethyl)-7-(2-(ethyl(2-hydroxyethyl)am...)
Affinity DataKi:  0.580nMAssay Description:Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484029(CHEMBL1801258)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50288405(CHEMBL95940 | N-[(1-Dihydroxyboranyl-4-guanidino-b...)
Affinity DataKi:  0.610nMAssay Description:Compound was tested in vitro for inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
Target5'-nucleotidase(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50583400(CHEMBL5078828)
Affinity DataKi:  0.626nMAssay Description:Inhibition of human soluble CD73 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50172117(2-Cyclohex-1-enylethynyl-pyridine | CHEMBL196643)
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]-3-methoxy-5-(pyridin-2-ylethynyl)pyridine from mGlu5 receptor of rat cortical membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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