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Target
Casein kinase I isoform alpha
Ligand
BDBM50588635
Substrate
n/a
Meas. Tech.
ChEMBL_2187930 (CHEMBL5100012)
IC50
220±n/a nM
Citation
 Wesseler, F; Lohmann, S; Riege, D; Halver, J; Roth, A; Pichlo, C; Weber, S; Takamiya, M; Müller, E; Ketzel, J; Flegel, J; Gihring, A; Rastegar, S; Bertrand, J; Baumann, U; Knippschild, U; Peifer, C; Sievers, S; Waldmann, H; Schade, D Phenotypic Discovery of Triazolo[1,5- J Med Chem 65:15263-15281 (2022) [PubMed] 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM50588635
Synonyms:
CHEMBL5186013
Type:
Small organic molecule
Emp. Form.:
C13H8BrN5O
Mol. Mass.:
330.14
SMILES:
Nc1nc2ccc(Br)cc2c2nc(nn12)-c1ccco1
Structure:
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