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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50122921
Substrate
n/a
Meas. Tech.
ChEMBL_124502 (CHEMBL733338)
IC50
171±n/a nM
Citation
 Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem 46:349-52 (2003) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50122921
Synonyms:
2-(2-Chloro-phenyl)-6-[2-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-4,5-dihydro-2H-pyridazin-3-one | 2-(2-chlorophenyl)-6-(2-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one | CHEMBL119675
Type:
Small organic molecule
Emp. Form.:
C24H16ClF3N4O
Mol. Mass.:
468.858
SMILES:
FC(F)(F)c1cccc(c1)-c1nc2ccccn2c1C1=NN(C(=O)CC1)c1ccccc1Cl |t:22|
Structure:
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