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Target
Coagulation factor X
Ligand
BDBM50154270
Substrate
n/a
Meas. Tech.
ChEMBL_304841 (CHEMBL827928)
IC50
160±n/a nM
Citation
 Haginoya, N; Kobayashi, S; Komoriya, S; Yoshino, T; Suzuki, M; Shimada, T; Watanabe, K; Hirokawa, Y; Furugori, T; Nagahara, T Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element. J Med Chem 47:5167-82 (2004) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50154270
Synonyms:
CHEMBL182957 | [4-(6-Chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(4,5,6,7-tetrahydro-thieno[2,3-c]pyridin-2-yl)-methanone
Type:
Small organic molecule
Emp. Form.:
C22H22ClN3O3S2
Mol. Mass.:
476.011
SMILES:
Clc1ccc2cc(ccc2c1)S(=O)(=O)N1CCN(CC1)C(=O)c1cc2CCNCc2s1
Structure:
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