Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50177327
Substrate
n/a
Meas. Tech.
ChEMBL_331857 (CHEMBL865873)
IC50
7820±n/a nM
Citation
 Cho, SYBaek, JYHan, SSKang, SKHa, JDAhn, JHLee, JDKim, KRCheon, HGRhee, SDYang, SDYon, GHPak, CSChoi, JK PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives. Bioorg Med Chem Lett 16:499-502 (2005) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50177327
Synonyms:
(S)-2-(4-(7-(4-methoxybenzoyl)cyclopenta[d][1,2]oxazin-4-yl)phenoxy)-3-phenylpropanoic acid | CHEMBL199479
Type:
Small organic molecule
Emp. Form.:
C30H23NO6
Mol. Mass.:
493.5067
SMILES:
COc1ccc(cc1)C(=O)c1ccc2c(nocc12)-c1ccc(O[C@@H](Cc2ccccc2)C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: