Reaction Details Report a problem with these data
Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50345890
Substrate
n/a
Meas. Tech.
ChEMBL_749421 (CHEMBL1786602)
IC50
140±n/a nM
Citation
 Lin, S; Lombardo, M; Malkani, S; Hale, JJ; Mills, SG; Chapman, K; Thompson, JE; Zhang, WX; Wang, R; Cubbon, RM; O'Neill, EA; Luell, S; Carballo-Jane, E; Yang, L Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett 19:3238-42 (2009) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50345890
Synonyms:
CHEMBL1783707 | tert-butyl 4-(3-((3-amino-6-ethylpyrazin-2-yl)methyl)thioureido)phenylcarbamate
Type:
Small organic molecule
Emp. Form.:
C19H26N6O2S
Mol. Mass.:
402.514
SMILES:
CCc1cnc(N)c(CNC(=S)Nc2ccc(NC(=O)OC(C)(C)C)cc2)n1
Structure:
Search PDB for entries with ligand similarity: