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Target
Beta-glucuronidase
Ligand
BDBM50183017
Substrate
n/a
Meas. Tech.
ChEMBL_1586150 (CHEMBL3821246)
IC50
9380±n/a nM
Citation
 Ali, F; Khan, KM; Salar, U; Iqbal, S; Taha, M; Ismail, NH; Perveen, S; Wadood, A; Ghufran, M; Ali, B Dihydropyrimidones: As novel class of฿-glucuronidase inhibitors. Bioorg Med Chem 24:3624-35 (2016) [PubMed]  Article 
Target
Name:
Beta-glucuronidase
Synonyms:
Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB
Type:
Protein
Mol. Mass.:
74467.69
Organism:
Bos taurus (Bovine)
Description:
EC 3.2.1.31, bovine liver
Residue:
652
Sequence:
MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGFEQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRVVLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHTLPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQDIGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYLYSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSNVSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVTFVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSEYGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVRMIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
  
Inhibitor
Name:
BDBM50183017
Synonyms:
CHEMBL3819636
Type:
Small organic molecule
Emp. Form.:
C14H13F3N2O3
Mol. Mass.:
314.2598
SMILES:
COC(=O)C1=C(C)NC(=O)NC1c1ccc(cc1)C(F)(F)F |c:4|
Structure:
Search PDB for entries with ligand similarity: