BDBM50345518 CHEMBL1784343::N-(1-((4-(2-(3,5-dimethylisoxazol-4-yl)ethyl)piperidin-1-ylsulfonyl)methyl)cyclobutyl)-N-hydroxyformamide::US10322143, Compound 14c

SMILES Cc1noc(C)c1CCC1CCN(CC1)S(=O)(=O)CC1(CCC1)N(O)C=O

InChI Key InChIKey=XRFARLVFDBABAU-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50345518   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-14 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-9 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50:  51nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-1 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-2 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human MMP-13 assessed as substrate cleavage after 20 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50345518(CHEMBL1784343 | N-(1-((4-(2-(3,5-dimethylisoxazol-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed