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Found 464 with Last Name = 'bantscheff' and Initial = 'm'
LigandPNGBDBM50506311(CHEMBL4462123)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50506332(CHEMBL4561242)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238434(CHEMBL4098952)
Affinity DataIC50:  2nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238419(CHEMBL4060134)
Affinity DataIC50:  2.5nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506325(CHEMBL4567736)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132G](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  2.90nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
LigandPNGBDBM50506346(CHEMBL4436659)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506328(CHEMBL4447804)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506333(CHEMBL4553962)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50506327(CHEMBL4449047)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506320(CHEMBL4436797)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506327(CHEMBL4449047)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  3.80nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
LigandPNGBDBM50506323(CHEMBL4556087)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50506331(CHEMBL4466265)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238417(CHEMBL4094551)
Affinity DataIC50:  4nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506320(CHEMBL4436797)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Homo sapiens (Human))
Albert Einstein College of Medicine

LigandPNGBDBM195601(GSK321 | US11311527, Cpd ID GSK321 | US11376246, C...)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:RapidFire-MS/MS measurements of mutant IDH1 and IDH2 reactions were conducted at room temperature in 384-well Greiner polypropylene microtiter plates...More data for this Ligand-Target Pair
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50506332(CHEMBL4561242)
Affinity DataIC50:  5nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506338(CHEMBL4533741)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238433(CHEMBL4080918)
Affinity DataIC50:  6.30nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238434(CHEMBL4098952)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506315(CHEMBL4579923)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50506326(CHEMBL4538635)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238448(CHEMBL4083872)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238418(CHEMBL4096094)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506325(CHEMBL4567736)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in cytostim-stimulated IFNgamma production preincubated for 1 hr followed by cytos...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506330(CHEMBL4580593)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506331(CHEMBL4466265)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238449(CHEMBL4089774)
Affinity DataIC50:  7.90nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506312(CHEMBL4519361)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238447(CHEMBL4101869)
Affinity DataIC50:  10nMAssay Description:Binding affinity against calf intestine adenosine deaminase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238437(CHEMBL4068794)
Affinity DataIC50:  10nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506310(CHEMBL4453668)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506318(CHEMBL4444082)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238436(CHEMBL4079594)
Affinity DataIC50:  16nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  16nMAssay Description:Inhibition of His-tagged TNKS1 (1091 to 1325 residues) (unknown origin) assessed as reduction in PARsylation of GST-tev-Axin2 preincubated for 30 min...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238422(CHEMBL4098529)
Affinity DataIC50:  16nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50506342(CHEMBL4448491)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506345(CHEMBL4472036)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506318(CHEMBL4444082)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50506329(CHEMBL4518946)
Affinity DataIC50:  16nMAssay Description:Inhibition of VPS34 in human HL60 cell extract measured after 2 hrs by kinobeads based pull down assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506327(CHEMBL4449047)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50506316(CHEMBL4545906)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110delta/human recombinant full-length untagged p85alpha expressed in baculovirus...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238446(CHEMBL4073498)
Affinity DataIC50:  20nMAssay Description:Binding affinity to TNKS1 in human HeLa cell extract after 2 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50238416(CHEMBL4087470)
Affinity DataIC50:  20nMAssay Description:Inhibition of TNKS1 (unknown origin) expressed in HEK293 cells co-expressing TCF/LEF luciferase plasmid assessed as reduction in wnt3a ligand-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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