BDBM112499 DACOMITINIB::US8623883, No. 2::WO2022090481, Example dacomitinib
SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
InChI Key InChIKey=LVXJQMNHJWSHET-AATRIKPKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 47 hits for monomerid = 112499
Affinity DataIC50: 6.90nMpH: 7.4 T: 25°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 74nMAssay Description:Inhibition of GST-tagged ERBB4 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 83.7nMpH: 7.4 T: 25°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of EGFR (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Irreversible inhibition of GST-tagged ERBB1 (unknown origin) (Met-668 to Ala-1211 residues) expressed in baculovirus infected Sf9 insect cells assess...More data for this Ligand-Target Pair
Affinity DataIC50: 3.57E+3nMAssay Description:Irreversible inhibition of human recombinant GST-tagged JAK3 expressed in baculovirus infected Sf9 insect cells assessed as reduction in polyglutamic...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of Src (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Irreversible inhibition of full length human ERBB1 autophosphorylation transfected in EGF-stimulated mouse NIH/3T3 cells incubated for 2 hrs followed...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Irreversible inhibition of GST-tagged ERBB4 (unknown origin) (Gly-259 to Gly-690 residues) expressed in baculovirus infected Sf9 insect cells assesse...More data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Irreversible inhibition of GST-tagged ERBB2 (unknown origin) (Ile-675 to Val-1256 residues) expressed in baculovirus infected Sf9 insect cells assess...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of GST-tagged ErbB4 expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged ErbB2 expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged EGFR expressed in sf9 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged human HER2 catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged human EGFR catalytic domain expressed in insect cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of wild type EGFR phosphorylation in human LoVo cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 42nMAssay Description:Inhibition of EGFR L858R/T970M double mutant phosphorylation in human NCI-H1975 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of HER2 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 9.40E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.57E+6nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human GST-fused EGFR kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of human GST-fused HER2 kinase domain expressed in baculovirus expression system measured after 30 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 978nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 0.640nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0100nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M](Human)
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 56nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,C797S](Human)
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.60nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.17E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Boehringer Ingelheim International
WIPO
Boehringer Ingelheim International
WIPO
Affinity DataIC50: 1.60E+3nMAssay Description: This assay quantifies the phosphorylation of EGFR at Tyr1068 and was used to measure the inhibitory effect of compounds on the transgenic EGFR del19...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) in human NCI-H1975 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Inhibition of EGF-stimulated wild-type EGFR phosphorylation in human A-431 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 40nMAssay Description:Inhibition of EGFR T790M mutant phosphorylation in human NCI-H1975 cells incubated for 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of EGFR phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of HER2 phosphorylation (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-tagged EGFR (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of GST-tagged ERBB2 (unknown origin) expressed in insect cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 16.7nMpH: 7.4 T: 25°CAssay Description:Inhibition of erbB tyrosine kinase activity was assessed using an ELISA-based receptor tyrosine kinase assay. Kinase reactions (50 mM HEPES, pH 7.4, ...More data for this Ligand-Target Pair