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BindingDB is a public, web-accessible database of measured binding affinities, focusing chiefly on the interactions of protein considered to be drug-targets with small, drug-like molecules. As of February 7, 2021, BindingDB contains 41,328 Entries, each with a DOI, containing 2,114,159 binding data for 8,202 protein targets and 928,022 small molecules.

There are 2823 protein-ligand crystal structures with BindingDB affinity measurements for proteins with 100% sequence identity, and 8263 crystal structures allowing proteins to 85% sequence identity.

You can also use BindingDB data through the Registry of Open Data on AWS: https://registry.opendata.aws/binding-db.

Simple Search
Article Titles, Authors, Assays, Compound Names, Target Names

Use ? for single-letter wild-card or * for general wild-card.
For example, "adeny*" or "adeny?". Query cannot start with wild card.
Advanced Search Combine multiple search criteria, such as chemical structures, target names, and numerical affinities; restrict searches by data source, such as BindingDB, ChEMBL, PubChem, and Patents.
Messages
  1. BindingDB is creating a focused collection of data on SARS-COV-2 and other coronaviruses. This is a work in progress! Please recommend useful papers or patents you may find, and let us know of any possible improvements.
Patent Curation
by BindingDB

BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of February 7, 2021, BindingDB's patent dataset comprises:

  1. Patents: 4,433
  2. Binding measurements: 652,622
  3. Compounds: 335,170
  4. Target proteins: 1,959
  5. Assays: 6,401
  6. Average Number of Targets per Patent: 1.90
Journal Curation
by BindingDB
BindingDB continually curates a set of journals not covered by other public databases. As of February 7, 2021, the status of our current curation effort is as follows:
  1. ACS Chemical Biology 2006-2017 (vol 1-12) magnifying glass
  2. ACS BioChemistry 1965-2017 (vol 4-56) magnifying glass
  3. Bioorganic Chemistry 1990-2017 (vol 18-73) magnifying glass
  4. BMC Chemical Biology 2001-2010 (vol 1-10) magnifying glass
  5. ChemBioChem 2001-2017 (vol 2-18) magnifying glass
  6. Chemical Biology & Drug Design 2006-2017 (vol 67-89) magnifying glass
  7. Chemistry & Biology 1995-2015 (vol 2-22) magnifying glass
  8. Journal of Biological Chemistry 1982-2014 (vol 257-289) magnifying glass
  9. Journal of Chemical Biology 2010-2010 (vol 3-3) magnifying glass
  10. Journal of Enzyme Inhibition and Medicinal Chemistry 2002-2014 (vol 17-29) magnifying glass
  11. Nature Chemical Biology 2005-2017 (vol 1-13) magnifying glass
  12. Medicinal Chemistry Research 2004-2014 (vol 13-23) magnifying glass
  1. PubMed IDs: 3,446
  2. Binding measurements: 110,330
  3. Compounds: 45,952
  4. Target proteins: 2,994
  5. Assays: 3,225
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Video Tutorials
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  3. Find and view all data for a target of interest
  4. Find my compound's targets