BDBM16005 2-[(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)amino]benzoic acid::4-anilinopyrimidine 8n::Bisanilinopyrimidine, 3c::US9249124, 4

SMILES OC(=O)c1ccccc1Nc1ccnc(Nc2ccc(cc2)N2CCOCC2)n1

InChI Key InChIKey=CQEYCBQCCXTCKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 16005   

TargetMitogen-activated protein kinase 8(Human)
Abbott Laboratories

LigandPNGBDBM16005(2-[(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4...)
Affinity DataIC50:  37nMAssay Description:In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM16005(2-[(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4...)
Affinity DataIC50:  57.6nMpH: 7.4 T: 25°CAssay Description:Reactions were carried out at room temperature in 15 mM HEPES buffer (pH 7.4) containing 20 mM NaCl, 1 mM EGTA, 0.02% Tween 20, 10 mM MgCl2, 5% (v/v)...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetAurora kinase A(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM16005(2-[(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4...)
Affinity DataIC50:  57.6nMAssay Description:In vitro enzyme activity assay using Aurora Kinase A. More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed