BDBM16099 3-carbamoyl-5-(4-phenylphenyl)benzoic acid::5-carbamoyl-1,1 :4 ,1 -terphenyl-3-carboxylic acid::AMX02::Brequinar-derived asymmetric terphenyl compound
SMILES: NC(=O)c1cc(cc(c1)-c1ccc(cc1)-c1ccccc1)C(O)=O
InChI Key: InChIKey=LAZPCGBRHLARSI-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dihydroorotate dehydrogenase (Homo sapiens (Human)) | BDBM16099![]() (3-carbamoyl-5-(4-phenylphenyl)benzoic acid | 5-car...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar | DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 2.80E+3 | -7.49 | n/a | n/a | n/a | n/a | n/a | 8.0 | 22 |
Cornell University | Assay Description The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect... | Bioorg Med Chem Lett 16: 1610-5 (2006) Article DOI: 10.1016/j.bmcl.2005.12.029 BindingDB Entry DOI: 10.7270/Q2H993FV | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |