BDBM16430 (2E)-3-phenylprop-2-enoic acid::CHEMBL27246::Cinnamic acid::Zimtsaeure::Zimtsaeure | trans-Cinnamate::t-Cinnamic acid::trans-Cinnamate

SMILES OC(=O)\C=C\c1ccccc1

InChI Key InChIKey=WBYWAXJHAXSJNI-VOTSOKGWSA-N

Data  5 KI  10 IC50

PDB links: 8 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 16430   

TargetHistone deacetylase(Human)
Hacettepe University

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataKi:  8.20nMAssay Description:Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Human)
Leiden University

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataKi:  4.90E+3nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in human HEK293T cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of [3H]NCS-382 binding to CaMK2alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Medical College of Wiscosin

LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataKi:  2.80E+5nM ΔG°:  -4.84kcal/molepH: 7.0 T: 25°CAssay Description:The production of NADPH from NADP+ and benzyl alcohol and xylitol was monitored by an increase in NADPH fluorescence (ex: 340 nm; em: 460 nm) using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1 [W220Y,C299A](Human)
Medical College of Wiscosin

LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataKi:  1.39E+6nMAssay Description:The production of NADPH from NADP+ and benzyl alcohol and xylitol was monitored by an increase in NADPH fluorescence (ex: 340 nm; em: 460 nm) using a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  685nMAssay Description:Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Human)
National Institute of Medicinal Materials

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  1.75E+5nMAssay Description:Inhibition of xanthine oxidase- mediated uric acid formation after 5 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-glucosidase MAL62(Baker's yeast)TBA
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 10 min before substrate addition and ...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAmyloid-beta precursor protein(Human)
University of Tsukuba

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  3.92E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-oxoacyl-[acyl-carrier-protein] synthase 3(Escherichia coli)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  4.34E+4nMAssay Description:Inhibition of N-terminal His-tagged Escherichia coli FabH expressed in Escherichia coli BL21 (DE3) using [3H]acetyl-coA after 25 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kinki University

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50: >3.50E+5nMAssay Description:Inhibition of mushroom tyrosinase after 25 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(White button mushroom)
Kinki University

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  4.10E+5nMAssay Description:Inhibition of mushroom tyrosinase after 10 mins by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Human)
Instituto Superior Técnico

LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  9.90E+6nMpH: 8.0Assay Description:AChE enzymatic activity was measured using an adaptation of the method previously described [Ingkaninan et al., J. Ethnopharmacol., 89:261-264]; 98 &...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM16430((2E)-3-phenylprop-2-enoic acid | CHEMBL27246 | Cin...)
Affinity DataIC50:  3.98E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed