BDBM1711 CHEMBL1684067::US8470837, 8

SMILES Cc1c(Nc2ccc(I)cc2F)c2c(ncn(C[C@@H](O)CO)c2=O)n(C)c1=O

InChI Key InChIKey=BUNLJQFWCXRHOQ-LLVKDONJSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 1711   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda California

Curated by ChEMBL

LigandBDBM1711(CHEMBL1684067 | US8470837, 8)Copy SMILESCopy InChI

Affinity DataIC50:  3.80nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetDual specificity mitogen-activated protein kinase kinase 1 [2-31,52-393,S218E,S222D](Human)
Takeda Pharmaceutical

US Patent

LigandBDBM1711(CHEMBL1684067 | US8470837, 8)Copy SMILESCopy InChI

Affinity DataIC50: <5nMpH: 7.3 T: 25°CAssay Description:Reaction product is determined quantitatively by fluorescent polarization using progressive IMAP beads from Molecular Devices.More data for this Ligand-Target Pair

Target InfoPDBMMDB
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails US Patent

Copy BDB DOI