BDBM17714 5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d]pyrimidin-4-amine::5,6-diphenylfuro[2,3-d]pyrimidin-4-amine, 1::CHEMBL247272

SMILES C(CN1CCNCC1)Nc1ncnc2oc(c(-c3ccccc3)c12)-c1ccccc1

InChI Key InChIKey=PTILEOLOGGMFCS-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17714   

LigandPNGBDBM17714(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Affinity DataIC50:  2.60E+3nMpH: 7.5 T: 22°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetActivated CDC42 kinase 1(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM17714(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Affinity DataIC50:  181nMAssay Description:Inhibition of Ack1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM17714(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Affinity DataIC50:  81nMAssay Description:Inhibition of LckMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetTyrosine-protein kinase Lck(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM17714(5,6-diphenyl-N-[2-(piperazin-1-yl)ethyl]furo[2,3-d...)
Affinity DataIC50:  81nMpH: 7.5 T: 22°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)