BDBM18799 2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-ethyl-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one::Pyrrolo[2,3-d]pyrimidine analogue, 5

SMILES CCc1[nH]c2nc(N)[nH]c(=O)c2c1Sc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=NPTOGSAVHKNFQL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 18799   

TargetDihydrofolate reductase(Human)
Duquesne University

LigandPNGBDBM18799(2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-ethyl-3...)
Affinity DataIC50: >2.70E+4nMpH: 7.4 T: 30°CAssay Description:DHFRs were assayed spectrophotometrically in the reaction buffer solution containing dihydrofolate. The reaction was initiated with an amount of enzy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidylate synthase(Escherichia coli (strain K12))
Duquesne University

LigandPNGBDBM18799(2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-ethyl-3...)
Affinity DataIC50: >2.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThymidylate synthase(Human)
Duquesne University

LigandPNGBDBM18799(2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-ethyl-3...)
Affinity DataIC50:  230nMpH: 7.4 T: 30°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed