BDBM19130 (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide::CHEMBL99::TSA::Trichostatin A (TSA)

SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C

InChI Key InChIKey=ALCVRKZFLFWUAZ-UHFFFAOYSA-N

Data  9 KI  174 IC50  2 Kd  4 EC50  1 ITC

PDB links: 14 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 189 hits for monomerid = 19130   

TargetHistone deacetylase 6(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.130nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of recombinant HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.260nMAssay Description:Displacement of fluorescent 5-(3-(3-(4-((4-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)phenylamino)methyl)-1H-1,2,3-triazol-1-yl)propyl)thioureido)-2-(3...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 3(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.580nMAssay Description:Inhibition of recombinant HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.760nMAssay Description:Inhibition of recombinant HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  0.990nMAssay Description:Inhibition of recombinant HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPolyamine deacetylase HDAC10(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  7nMAssay Description:Inhibition of HDAC10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 8(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  130nMAssay Description:Inhibition of recombinant HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase-like amidohydrolase(Alcaligenes sp. (strain DSM 11172) (Bordetella sp....)
University of G£Ttingen

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKi:  700nMAssay Description:Displacement of Atto700-HA from Bordetella/Alcaligenes strain FB188 HDAH by fluorescence anisotropyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Mouse)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  81nMpH: 8.0 T: 37°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  21nMpH: 8.0 T: 37°CAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  34nMAssay Description:The enzyme activity was assayed using recombinant HDAC and [3H] acetyl-labeled histones as substrate. The released [3H]acetic acid was extracted and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  19nMpH: 8.0 T: 37°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  20nMpH: 8.0 T: 37°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Mouse)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  28nMpH: 8.0 T: 37°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  4nMpH: 7.5 T: 25°CAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  14nMpH: 7.5 T: 25°CAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 3(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 8(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.38E+3nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetPolyamine deacetylase HDAC10(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  5nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1nMAssay Description:The inhibitory effects of compounds on histone deacetylase (HDAC) activity were determined using a fluorescence-based assay with electrophoretic sepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetLysine-specific demethylase 4E(Human)
University of Oxford

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2.80E+4nMpH: 7.5 T: 37°CAssay Description:For compounds which were shown to inhibit FDH, a MALDI-TOF-MS inhibition assay was employed. After incubation, the diluted assay mixture was then mix...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.600nMpH: 7.5 T: 23°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 8(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKd:  490nMAssay Description:To determine the dissociation rate of the inhibitor, 1 µM HDAC8 and 20 µM inhibitor (syringe I) were mixed with 100 µM c-SAHA (syringe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 8(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataKd:  390nMpH: 7.5Assay Description:A fixed concentration of 1.5 µM was titrated with an increasing concentration of the respective inhibitor in protein storage buffer containing 5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  5nMAssay Description:In vitro inhibition of partially purified recombinant human Histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human recombinant HDAC5 using fluorophore-conjugated substrate Boc-L-Lys(Ac)-AMC after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Mouse)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of mouse HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  3nMAssay Description:Inhibition of maize Histone deacetylase 2 (HD-2) activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC5 by in vitro deacetylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 5(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human HDAC5 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against histone deacetylase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7nMAssay Description:In vitro for anti-HD2 (Histone deacetylase 2) activity in maizeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2nMAssay Description:In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  3nMAssay Description:Inhibition of in vitro enzyme activity measured in a highly purified maize Histone deacetylase 2 preparationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of maize histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7.20nMAssay Description:Concentration required for inhibition of histone deacetylase HD2 in vitro.Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  39nMAssay Description:Inhibitory concentrationagainst histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  91nMAssay Description:Inhibitory concentration against histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  20nMAssay Description:Inhibitory concentration against histone deacetylase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 6(Human)
The Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  81nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  21nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 4(Human)
Nagoya City University

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  34nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase(Maize)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of maize HD1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 2b(Maize)
WestfäLische Wilhelms-UniversitäT MüNster

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of maize HD2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone deacetylase 1(Human)
University of Poitiers

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  26nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

Displayed 1 to 50 (of 189 total ) | Next | Last >>

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 19130   

CellHistone deacetylase 1/3/5/8(Human)
North Dakota State University

SyringePNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
ITC DataΔG°: -8.60kcal/mole −TΔS°: 0.214kcal/mole ΔH°: -8.84kcal/mole logk: 2.03E+6
T: 25.00°C