BDBM2068 2-ethyl-13-(2-hydroxyethyl)-9-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one::8-Substituted Dipyridodiazepinone 9

SMILES CCN1c2ncccc2N(C)C(=O)c2cc(CCO)cnc12

InChI Key InChIKey=LSDLBGOYTYAGQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 2068   

TargetGag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM2068(2-ethyl-13-(2-hydroxyethyl)-9-methyl-2,4,9,15-tetr...)
Affinity DataIC50:  2.50E+3nMpH: 7.8 T: 22°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGag-Pol polyprotein [600-1027,R876K]/[600-1155](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM2068(2-ethyl-13-(2-hydroxyethyl)-9-methyl-2,4,9,15-tetr...)
Affinity DataIC50:  430nMpH: 7.8 T: 22°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed