BDBM22165 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine::CHEMBL153260::CHEMBL281594::CHEMBL542933::CHEMBL543876::GBR 12909::GBR-12909::NCGC00015300::US9944618, Compound ID No. 175::Vanoxerine

SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1

InChI Key InChIKey=NAUWTFJOPJWYOT-UHFFFAOYSA-N

Data  106 KI  92 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 198 hits for monomerid = 22165   

TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.0600nMAssay Description:In vitro binding affinity towards dopamine transporter in rat striatal membranes by [3H]GBR-12395 displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.150nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.430nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  0.880nMAssay Description:Inhibitory constant towards reuptake of [125I]-12 from dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  1.43nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  2.42nMAssay Description:Displacement of [125I]IPT from DAT overexpressed in LLC-PK1 cell membrane by competitive binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nM ΔG°:  -10.7kcal/molepH: 7.4 T: 4°CAssay Description:The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against Dopamine transporter using [125]RTI-55More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Affinity at rat dopamine transporter using [125I]-RTI-55 displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporter (DAT)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity of the compound towards dopamine transporter (DAT)More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity of the compound towards dopmine transporter(DAT) by using [125I]-RTI-55 radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity for dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity against dopamine transporter labelled with [125I]- RTI-55 in rat.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [125I]RTI55 from DAT in rat brain synaptosomesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.70nMAssay Description:Binding affinity at dopamine transporter in rat brain by [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  3.80nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.30nMAssay Description:Inhibition of [3H]-dopamine uptake via rat dopamine receptor.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  4.70nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK cell membrane assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  5.07nMAssay Description:Inhibition of [3H]dopamine reuptake at dopamine transporterMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.60nMAssay Description:Inhibition of [3H]WIN 35428 binding to rat striatum DATMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.70nMAssay Description:DAT: This protocol was designed to measure inhibition of uptake by the human dopamine transporter. The reagents were human DAT (HEK293F) cells, GBR 1...More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 minsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  8.80nMAssay Description:Displacement of [3H]-WIN35428 from human DAT expressed in HEK293 cells measured after 30 minsMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10nMAssay Description:Inhibitory constant towards reuptake of [125I]-13 from dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.2nMAssay Description:Displacement of [3H]WIN-from DAT in rat striatumMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of [3H]dopamine uptake in DAT in rat striatumMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  10.6nMAssay Description:Inhibition of rat brain dopamine transporter as accumulation of [3H]-DAMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  11nMAssay Description:Inhibition of DAT-mediated [3H]DA uptake in rat striatumMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  11.9nMAssay Description:Binding affinity against dopamine transporter was determined by the displacement of [3H]WIN-35428 radioligand in rat brainMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Compound was evaluated for its ability to displace [3H]WIN-35428 binding in rat caudate-putamenMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity to dopamine transporter (DAT) using [3H]WIN-35428 as a radioligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity Sprague-Dawley rats using [3H]WIN-35428 ligandMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity at dopamine transporter from rat caudate-putamen tissue by [3H]-WIN- 35428 displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Mouse)
University of Missouri

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]RTI-121 from mouse DAT in striatal membranesMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Affinity for rat dopamine transporter using [3H]WIN-35428 displacement.More data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Displacement of [3H]WIN-35428 from dopamine transporter of rat caudate putamen tissueMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  12nMAssay Description:Binding affinity at Dopamine transporter by displacing [3H]WIN-35428 from rat caudate putamenMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  16.2nMAssay Description:Inhibition of DAT in rat striatum assessed as [3H]dopamine accumulationMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Rat)
Novo Industri

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  18nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rat)
Research Biochemicals International

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  18nMAssay Description:Inhibition of [3H]DA uptake at DAT in rat brain striatal synaptosomes by liquid scintillation spectrophotometryMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Human)
University of Toronto

Curated by PDSP Ki Database
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]WIN35428 from DAT after 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM22165(1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...)
Affinity DataKi:  24nMAssay Description:Binding affinity against Serotonin transporter in male Sprague-Dawley rats using [3H]paroxetine ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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