BDBM22893 CHEMBL512::Ranitidine::ZANTAC::dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine
SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
InChI Key InChIKey=HZIQBJWHRYXWSD-UHFFFAOYSA-O
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 22893
TargetHistamine H2 receptor(Guinea pig)
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
TargetHistamine H2 receptor(Guinea pig)
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 501nMAssay Description:In vitro inhibition of Histamine H2 receptor by measuring its ability to block the histamine-stimulated adenylate cyclase of guinea pig hippocampal h...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Human)
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
TargetHistamine H3 receptor(Human)
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
R. W. Johnson Pharmaceutical Research Institute
Curated by PDSP Ki Database
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:The compound was evaluated for the inhibition of human AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of guinea pig acetylcholinesteraseMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Human)
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Guinea pig)
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Affinity DataIC50: 3.40E+3nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair