BDBM23701 4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole::N-Benzoylpyrazole deriv., 3

SMILES [O-][N+](=O)c1cccc(c1)C(=O)n1cc(Cl)cn1

InChI Key InChIKey=BKMXGSZQEWHCJH-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23701   

TargetNeutrophil elastase(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  24nM ΔG°:  -10.4kcal/molepH: 7.5 T: 25°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProthrombin(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50:  680nMAssay Description:Thrombin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCathepsin D(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:Cathepsin D assays were monitored with a Fluoroskan Ascent FL microtiter plate reader at excitation and emission wavelengths of 340 and 390 nm, respe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPlasma kallikrein(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50:  1.13E+4nMAssay Description:Kallikrein activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAminopeptidase N(Pig)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataAssay Description:Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetChymotrypsin-C(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50:  340nMAssay Description:Chymotrypsin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetUrokinase-type plasminogen activator(Human)
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataIC50:  170nMAssay Description:Urokinase activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed