BDBM24776 1,4-Naphthoquinone::1,4-Naphthoquinone (5a)::1,4-dihydronaphthalene-1,4-dione::1,4-naphtho-quinone, 3::CHEMBL55934

SMILES O=C1C=CC(=O)c2ccccc12

InChI Key InChIKey=FRASJONUBLZVQX-UHFFFAOYSA-N

Data  2 KI  17 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 24776   

TargetAmine oxidase [flavin-containing] B(Human)
Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataKi:  1.50E+3nMAssay Description:Competitive inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells using benzylamine as substrate by Lineweaver-Burk pl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataKi:  7.70E+3nMAssay Description:Noncompetitive inhibition of human recombinant MAO-A expressed in baculovirus infected insect cells using p-tyramine as substrate by Lineweaver-Burk ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
Federal University of Rio De Janeiro

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  3.43E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase(Human)
North-West University

LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  8.40E+3nMAssay Description:The protocol for measuring IC50 values for the inhibition of MAO-A and MAO-B has been reported in detail in a recent publication (26). The recombinan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetGenome polyprotein(Human rhinovirus B)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibitory activity against HRV 3Cpro using HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPapain(Papaya)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibitory activity against papain using HPLC assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetM-phase inducer phosphatase 2(Human)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  2.76E+3nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein phosphatase 1(Mouse)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  8.45E+3nMAssay Description:Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity protein phosphatase 6(Rat)
Virginia Polytechnic Institute and State University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIndoleamine 2,3-dioxygenase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  990nMAssay Description:Inhibition of 2,3 dioxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of recombinant AKT1 (unknown origin) using serine/threonine 06 peptide as substrate after 1 hr by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  380nMAssay Description:Inhibition of MEK1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIndoleamine 2,3-dioxygenase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  460nMAssay Description:Compound was tested in a cell-free SLe-polyacrylamide glycoconjugate binding assay (assay B) in Selectin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EHMT2(Human)
Radboud University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of wild type recombinant human histone lysine methyltransferase G9a (913 to 1193 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetHistone-lysine N-methyltransferase EHMT1(Human)
Radboud University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of wild type recombinant human histone lysine methyltransferase GLP (951 to 1235 residues) expressed in Escherichia coli Rosetta BL21 DE3 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIndoleamine 2,3-dioxygenase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human IDO1 using L-tryptophan as substrate incubated under dark conditions measured after 60 mins by fluorescence microplat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPeptidyl-prolyl cis-trans isomerase NIMA-interacting 1(Human)
Chinese Academy of Medical Sciences & Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human recombinant Pin1 using Suc-AEPF-NH-Np as substrate by alpha-chymotrypsin based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAlpha-synuclein(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of wild type human alpha-synuclein fibrillization expressed in Escherichia coli BL21(DE3)pLysS by thioflavin-T based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetIndoleamine 2,3-dioxygenase 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataIC50:  990nMpH: 6.5 T: 37°CAssay Description:The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbon monoxide dehydrogenase small chain(Oligotropha carboxidovorans)
University of California Riverside

LigandPNGBDBM24776(1,4-Naphthoquinone | 1,4-Naphthoquinone (5a) | 1,4...)
Affinity DataKd:  1.40E+5nMAssay Description:Inhibition of CODH by Diphenyliodomium chloride. Inactivation of the FAD cofactor of CODH was accomplished by covalent modification of the flavin wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed