BDBM249306 US10017501, Compound 1020-104::US9458145, 1020-104

SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1

InChI Key InChIKey=CMSUJGUHYXQSOK-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 249306   

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249306(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Affinity DataKi:  7.20nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249306(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Affinity DataKi:  11.7nMAssay Description:Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249306(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Affinity DataIC50:  7.20nMpH: 7.5 T: 25°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Gilead Sciences

US Patent
LigandPNGBDBM249306(US10017501, Compound 1020-104 | US9458145, 1020-10...)
Affinity DataIC50:  11.7nMpH: 7.5 T: 25°CAssay Description:The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi...More data for this Ligand-Target Pair
In DepthDetails US Patent