BDBM27660 4-Benzyl-2H-phthalazin-1-one::4-benzyl-1,2-dihydrophthalazin-1-one::4-benzylphthalazin-1(2H)-one::CHEMBL66761::US20230159469, Example 143::phthalazinone, 1

SMILES O=c1[nH]nc(Cc2ccccc2)c2ccccc12

InChI Key InChIKey=JUCCMEHWBGPJKS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 27660   

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(4-Benzyl-2H-phthalazin-1-one | 4-benzyl-1,2-dihydr...)
Affinity DataIC50:  770nMpH: 7.4 T: 22°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(4-Benzyl-2H-phthalazin-1-one | 4-benzyl-1,2-dihydr...)
Affinity DataIC50:  770nMAssay Description:Inhibitory concentration against human poly (ADP-ribose) polymerase 1 (PARP-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27660(4-Benzyl-2H-phthalazin-1-one | 4-benzyl-1,2-dihydr...)
Affinity DataIC50: >1.00E+4nMAssay Description:ENPP1 hydrolyzes nucleotides or nucleotide derivatives to produce nucleoside -5′-monophosphate and pyrophosphate. in addition, ENPP1 hydrolyzes...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Kudos Pharmaceuticals

LigandPNGBDBM27660(4-Benzyl-2H-phthalazin-1-one | 4-benzyl-1,2-dihydr...)
Affinity DataIC50:  770nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Human)
Ochanomizu University

Curated by ChEMBL
LigandPNGBDBM27660(4-Benzyl-2H-phthalazin-1-one | 4-benzyl-1,2-dihydr...)
Affinity DataIC50:  5.37E+3nMAssay Description:Antagonist activity at wild type AR expressed in human SC cells assessed as inhibition of 1 nM DHT-induced cell proliferation after 3 days by WST-8 a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed