BDBM29143 CHEMBL7976::Chalcone 1::Chalcone, 13::cid_637760::substituted chalcone, 5j

SMILES O=C(\C=C\c1ccccc1)c1ccccc1

InChI Key InChIKey=DQFBYFPFKXHELB-VAWYXSNFSA-N

Data  3 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 29143   

TargetAmine oxidase [flavin-containing] B(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataKi:  56nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI cells assessed as inhibition of H2O2 production using kynuramine as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataKi:  1.46E+4nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI cells assessed as inhibition of H2O2 production using kynuramine as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPancreatic alpha-amylase(Pig)
Freie Universit£T Berlin

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataKi:  4.80E+4nMAssay Description:Inhibition of porcine pancreatic alpha-amylase using soluble starch as substrate after 30 mins by Bernfeld methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPerilipin-5(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  4.25E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay

TargetCarboxylic ester hydrolase(Horse)
Quaid-I-Azam University

LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  1.09E+5nMpH: 8.0 T: 25°CAssay Description:In vitro cholinesterase inhibition assay using electric-eel acetylcholinesterase, horse-serum butyrylcholinesterse. The IC50 values were calculated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetStromal cell-derived factor 1(Human)
UniversitÉ

LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50: >5.00E+5nMT: 20°CAssay Description:Binding of chalcone 4 and chlcone 1 to CSCL12 was examined by monitoring changes in the emission intensity of intrinsic Trp fluorescence of the chemo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCholinesterase(Human)
University of Florida

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  8.70E+4nMAssay Description:Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of TNF-alpha-induced VCAM-1 expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetDihydrofolate reductase(Human)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant dihydrofolate reductase using dihydrofolate as substrate measured every 30 secs over 6 mins by UV/visible spectrophot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPolyunsaturated fatty acid 5-lipoxygenase(Mouse)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  1.22E+4nMAssay Description:Inhibitory activity against murine lipoxygenase-2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 2(Mouse)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibitory activity against murine Prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetProstaglandin G/H synthase 1(Mouse)
Yeungnam University

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  2.21E+4nMAssay Description:Inhibitory activity against murine prostaglandin G/H synthase 1.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  4.30E+4nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article

TargetAndrogen receptor(Rat)
University of Basel

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  6.46E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThioredoxin reductase 1, cytoplasmic(Rat)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  4.64E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetThioredoxin reductase 1, cytoplasmic(Rat)
National University of Singapore

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  2.67E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] B(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  1.41E+6nMAssay Description:Inhibition of MAO-B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPancreatic triacylglycerol lipase(Pig)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  8.44E+4nMAssay Description:Inhibition of porcine pancreatic lipase preincubated for 10 mins followed by 4-MUO addition and measured at 60 sec interval for 40 mins by multi plat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetPerilipin-1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  4.19E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay

TargetSortase family protein(Staphylococcus aureus)
Indian Institute of Technology Delhi

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  5.32E+4nMAssay Description:Inhibition of human rhodamine-labelled soluble CD69 by standard plate inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] B(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  1.41E+3nMpH: 7.4 T: 37°CAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetAmine oxidase [flavin-containing] A(Human)
University of Pavia

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataAssay Description:The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed