BDBM50026486 (Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid::7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid::CHEMBL28196::Isbogrel

SMILES OC(=O)CCCC\C=C(\c1ccccc1)c1cccnc1

InChI Key InChIKey=UWPBQLKEHGGKKD-BOPFTXTBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50026486   

TargetThromboxane-A synthase(Human)
Nikken Chemicals

Curated by ChEMBL
LigandPNGBDBM50026486((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibition of thromboxane synthase (TXA2) in human platelet microsomes [reduced formation of TXB2 from prostaglandin H2(PGH2)]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Human)
Nikken Chemicals

Curated by ChEMBL
LigandPNGBDBM50026486((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)
Affinity DataIC50:  51nMAssay Description:Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Human)
Nikken Chemicals

Curated by ChEMBL
LigandPNGBDBM50026486((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)
Affinity DataIC50:  51nMAssay Description:Inhibitory activity against thromboxane B2 formation (TXA2 synthase) by incubating prostaglandin H2 (PGH-2) with horse platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThromboxane-A synthase(Human)
Nikken Chemicals

Curated by ChEMBL
LigandPNGBDBM50026486((Z)-7-Phenyl-7-pyridin-3-yl-hept-6-enoic acid | 7-...)
Affinity DataIC50:  0.900nMAssay Description:Thromboxane A2 synthase inhibitory activity was measured from inhibition of thromboxane B2 production in human platelet microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed