BDBM50027970 5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-diamine::Brodimoprim::CHEMBL31891

SMILES COc1cc(Cc2cnc(N)nc2N)cc(OC)c1Br

InChI Key InChIKey=BFCRRLMMHNLSCP-UHFFFAOYSA-N

Data  5 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50027970   

TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataKi:  0.603nMAssay Description:Inhibition constant against binding of Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Salmonella typhi)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataKi:  6.60nMAssay Description:Inhibitory activity against Escherichia coli dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataKi:  11nMAssay Description:Inhibition constant of compound against L. casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataKi:  52nMAssay Description:Inhibitory activity against Lactobacillus casei dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Chicken)
Pomona College

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataKi:  2.88E+4nMAssay Description:Inhibitory activity against chicken liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rat)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataIC50:  15nMAssay Description:Inhibition of rat liver Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Escherichia coli)
Uniroyal Chemical

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataIC50:  3nMAssay Description:Compound was tested for inhibition of Escherichia coli Dihydrofolate reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataIC50:  17nMAssay Description:Inhibition of T. gondii Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50027970(5-(4-Bromo-3,5-dimethoxy-benzyl)-pyrimidine-2,4-di...)
Affinity DataIC50:  31nMAssay Description:Inhibition of P. carinii Dihydrofolate ReductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed