BDBM50033332 4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid methyl ester::CHEMBL120099

SMILES COC(=O)c1ccc(Nc2nc(nc3ccccc23)-c2ccccc2)cc1

InChI Key InChIKey=YNJLEXNLBZQNTP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50033332   

LigandPNGBDBM50033332(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Affinity DataIC50:  860nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50033332(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of ABCC1 in human H69AR cells preincubated for 30 mins before calcein AM addition by calcein AM assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50033332(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Affinity DataIC50:  944nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Hoechst 33342 addition by Hoechst 33342 accu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50033332(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Affinity DataIC50:  944nMAssay Description:Inhibition of c-terminal GFP-tagged human ABCG2 expressed in MDCK2 cells preincubated for 30 mins before Hoechst 33342 addition by Hoechst 33342 accu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Human)
University of Bonn

Curated by ChEMBL
LigandPNGBDBM50033332(4-(2-Phenyl-quinazolin-4-ylamino)-benzoic acid met...)
Affinity DataIC50:  8.13E+3nMAssay Description:Inhibition of ABCC1 in human H69AR cells preincubated for 30 mins before calcein AM addition by calcein AM assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed