BDBM50049066 2-Hydroxynaphthoquinone::CHEBI:44401::Lawsone::NSC-8625

SMILES OC1=CC(=O)c2ccccc2C1=O

InChI Key InChIKey=CSFWPUWCSPOLJW-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50049066   

TargetTyrosine-protein phosphatase non-receptor type 22(Human)
University of Utah

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of LYP (unknown origin) using DiFMUP substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Mouse)
Instituto Oswaldo Cruz

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50:  7.55E+4nMAssay Description:Antagonist activity at P2X7R in Swiss Webster mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake preincubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate by fluorimetric analysis relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase SETD7(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of SET7 (unknown origin) using biotinylated histone polypeptide as substrate in presence of SAM by AlphaLISA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteine protease(Trypanosoma brucei rhodesiense)
Federal University of Alagoas

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Blood fluke)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50049066(2-Hydroxynaphthoquinone | CHEBI:44401 | Lawsone | ...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed