BDBM50057525 4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide::CHEMBL283038

SMILES Cc1ccc(-c2cc(nn2-c2ccc(cc2)S(N)(=O)=O)C(F)(F)F)c(C)c1

InChI Key InChIKey=CDMHSMOZNZFYIK-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50057525   

TargetProstaglandin G/H synthase 1(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  8.18E+4nMAssay Description:In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  120nMAssay Description:Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSarcoplasmic/endoplasmic reticulum calcium ATPase 1(Rabbit)
University of Chemistry and Technology Prague

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of rabbit skeletal muscle microsomes SERCA1aMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Sheep)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  8.13E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mouse)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  120nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Human)
Searle Research and Development

Curated by ChEMBL
LigandPNGBDBM50057525(4-[5-(2,4-Dimethyl-phenyl)-3-trifluoromethyl-pyraz...)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed