BDBM50091145 (S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)methyl)(methyl)amino)benzamido)pentanedioic acid::2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid::CHEMBL104829::FURO[2,3D]PYRIMIDINE ANTIFOLATE::N-[4-[(2,4-DIAMINOFURO[2,3D]PYRIMIDIN-5-YL)METHYL]METHYLAMINO]-BENZOYL]-L-GLUTAMATE

SMILES CN(Cc1coc2nc(N)nc(N)c12)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI Key InChIKey=WXINNGCGSCFUCR-ZDUSSCGKSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50091145   

TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  220nMAssay Description:Inhibitory concentration against Lactobacillus casei Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  220nMAssay Description:Inhibitory concentration against recombinant human (rh) Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  1.98E+4nMAssay Description:Inhibitory concentration against Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory concentration against recombinant human (rh) Thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  220nMpH: 7.4Assay Description:Inhibition of human DHFR at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory concentration against human Thymidylate synthase(TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50:  220nMAssay Description:Inhibitory concentration against human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50: >2.00E+5nMpH: 7.4Assay Description:Inhibition of human thymidylate synthase at 30 degC under pH 7.4 by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50091145((S)-2-(4-(((2,4-diaminofuro[2,3-d]pyrimidin-5-yl)m...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibitory concentration against Lactobacillus casei Thymidylate synthase (TS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed